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Breast cancer risk in relation to plasma metabolites among Hispanic and African American women

Breast Cancer Research and Treatment volume 176, pages 687–696 (2019)Cite this article

A Correction to this article was published on 01 June 2019

This article has been updated

Abstract

Purpose

The metabolic etiology of breast cancer has been explored in the past several years using metabolomics. However, most of these studies only included non-Hispanic White individuals.

Methods

To fill this gap, we performed a two-step (discovery and validation) metabolomics profiling in plasma samples from 358 breast cancer patients and 138 healthy controls. All study subjects were either Hispanics or non-Hispanic African Americans.

Results

A panel of 14 identified metabolites significantly differed between breast cancer cases and healthy controls in both the discovery and validation sets. Most of these identified metabolites were lipids. In the pathway analysis, citrate cycle (TCA cycle), arginine and proline metabolism, and linoleic acid metabolism pathways were observed, and they significantly differed between breast cancer cases and healthy controls in both sets. From those 14 metabolites, we selected 9 non-correlated metabolites to generate a metabolic risk score. Increased metabolites risk score was associated with a 1.87- and 1.63-fold increased risk of breast cancer in the discovery and validation sets, respectively (Odds ratio (OR) 1.87, 95% Confidence interval (CI) 1.50, 2.32; OR 1.63, 95% CI 1.36, 1.95).

Conclusions

In summary, our study identified metabolic profiles and pathways that significantly differed between breast cancer cases and healthy controls in Hispanic or non-Hispanic African American women. The results from our study might provide new insights on the metabolic etiology of breast cancer.

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Fig. 1

Change history

  • 01 June 2019

    In the original publication of the article, the sixth author name Krita A. Zanetti was mistakenly included as co-author. The corrected author group is given in the correction article. The original article has been corrected.

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Acknowledgements

The study was supported by U01 CA179655 from NCI/NIH.

Author information

Affiliations

  1. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Hua Zhao, Jie Shen, Yuanqing Ye, Xifeng Wu & Wong-Ho Chow

  2. Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, racial Houston, TX, 77030, USA

    Debasish Tripathy

  3. Divisions of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA

    Steven C. Moore

  4. Perlmutter Cancer Center at New York University Langone Health, New York, NY, 10016, USA

    Francisco J. Esteva

Authors
  1. Hua Zhao
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  2. Jie Shen
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  3. Steven C. Moore
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  4. Yuanqing Ye
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  5. Xifeng Wu
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  7. Debasish Tripathy
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  8. Wong-Ho Chow
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Correspondence to Hua Zhao.

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All procedures performed in this study were approved by the Institutional Review Board at M D Anderson Cancer Center and in accordance with the ethical standards of 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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The original version of this article was revised: The sixth author name Krita A. Zanetti was mistakenly included as co-author. The author group was corrected.

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Zhao, H., Shen, J., Moore, S.C. et al. Breast cancer risk in relation to plasma metabolites among Hispanic and African American women. Breast Cancer Res Treat 176, 687–696 (2019). https://doi.org/10.1007/s10549-019-05165-4

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Keywords

  • Metabolomics
  • Breast cancer
  • Racial minority