Skip to main content

Advertisement

Log in

Clinical implication of E-cadherin deficiency in lobular breast cancer

  • Letter to the Editor
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Teo K, Gómez-Cuadrado L, Tenhagen M, Byron A, Rätze M, van Amersfoort M et al (2018) E-cadherin loss induces targetable autocrine activation of growth factor signalling in lobular breast cancer. Sci Rep 8(1):15454. https://doi.org/10.1038/s41598-018-33525-5

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Christofori G, Semb H (1999) The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 24(2):73–76

    Article  PubMed  CAS  Google Scholar 

  3. Takeichi M (1993) Cadherins in cancer: implications for invasion and metastasis. Curr Opin Cell Biol 5(5):806–811

    Article  PubMed  CAS  Google Scholar 

  4. Corso G, Carvalho J, Marrelli D, Vindigni C, Carvalho B, Seruca R et al (2013) Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer. J Clin Oncol 31(7):868–875. https://doi.org/10.1200/JCO.2012.44.4612

    Article  PubMed  CAS  Google Scholar 

  5. Berx G, Cleton-Jansen AM, Nollet F, de Leeuw WJ, van de Vijver M, Cornelisse C et al (1995) E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J 14(24):6107–6115

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Iorfida M, Maiorano E, Orvieto E, Maisonneuve P, Bottiglieri L, Rotmensz N et al (2012) Invasive lobular breast cancer: subtypes and outcome. Breast Cancer Res Treat 133(2):713–723. https://doi.org/10.1007/s10549-012-2002-z

    Article  PubMed  CAS  Google Scholar 

  7. Colleoni M, Russo L, Dellapasqua S (2011) Adjuvant therapies for special types of breast cancer. Breast 20(Suppl 3):S153–S157. https://doi.org/10.1016/S0960-9776(11)70315-0

    Article  PubMed  Google Scholar 

  8. Mateus AR, Simões-Correia J, Figueiredo J, Heindl S, Alves CC, Suriano G et al (2009) E-cadherin mutations and cell motility: a genotype-phenotype correlation. Exp Cell Res 315(8):1393–1402. https://doi.org/10.1016/j.yexcr.2009.02.020

    Article  PubMed  CAS  Google Scholar 

  9. Mateus AR, Seruca R, Machado JC, Keller G, Oliveira MJ, Suriano G et al (2007) EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells. Hum Mol Genet 16(13):1639–1647

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This manuscript was supported by the Italian Ministry of Health (Project Code: GR-2016-02361655. “Understanding how CDH1 germline mutations affect hereditary lobular breast cancer”).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Giovanni Corso.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Informed consent

Not necessary for this study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Corso, G., Pravettoni, G., Galimberti, V. et al. Clinical implication of E-cadherin deficiency in lobular breast cancer. Breast Cancer Res Treat 173, 751–752 (2019). https://doi.org/10.1007/s10549-018-5051-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10549-018-5051-0

Navigation