Abstract
Purpose
Breast cancer survivors face numerous challenges after diagnosis and treatment. Several models have been developed to attempt to improve quality of care. Here, we describe characteristics and outcomes of patients who participated in survivorship visits (SV) at Johns Hopkins (JH).
Methods
We retrospectively reviewed charts of breast cancer patients who participated in an optional SV 1–3 months after completing locoregional therapy and initial systemic therapy. We report patient demographics, comorbidities, tumor characteristics, treatments, and responses to symptom questionnaires. We compared the characteristics of SV participants to stage I–III analytical cases in the 2010–2015 JH Cancer Registry (JHCR).
Results
We identified 87 women with stage I–III breast cancer who participated in SVs from 2010 to 2016. Compared to patients in the JHCR (n = 2942), SV participants were younger, more likely to be African American and more likely to have a higher TNM stage, hormone receptor-negative disease, and HER2-positive disease. They were more likely to have received chemotherapy and radiation therapy. They also have similar recurrence rates despite the SV cohort’s shorter median follow-up time. Among SV participants, the prevalence of comorbidities including peripheral neuropathy, anemia, lymphedema, anxiety, deep vein thrombosis, and depression increased significantly from time of diagnosis to most recent follow-up.
Conclusions
Compared to the JHCR cohort, SV participants had higher risk cancers and a high frequency of comorbidities potentially associated with breast cancer and therapy. These high-risk patients may benefit most from specific interventions targeting survivorship care, and their experiences may help improve care delivery models.
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Funding
This study was funded by the Susan G. Komen Leadership Grant SAC110053 and SAC 170001 (A.C.W.), Susan G. Komen Maryland (A.C.W. and E.T.B.), and National Institutes of Health Grant P30CA006973.
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Contributions
SS, AW, EB: Concept and design, SS, JR: Collection and assembly of data, All authors: Data analysis and interpretation, All authors: Manuscript writing, All authors: Final approval of manuscript.
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Conflict of interest
SS, JS, NZ, CR, JR, KCS, and AC declare no conflicts of interest. CS receives funding from Genentec. KLS receives funding from the National Comprehensive Cancer Network and Pfizer. VS receives funding from Pfizer, Novartis, Medimmune, Puma, and AbbVie.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Human and animal rights
This article does not contain any studies with animals performed by any of the authors.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Additional information
Previously Presented: The San Antonio Breast Cancer Symposium, December 05–09, 2017.
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Skuli, S.J., Sheng, J.Y., Bantug, E.T. et al. Survivorship care visits in a high-risk population of breast cancer survivors. Breast Cancer Res Treat 173, 701–708 (2019). https://doi.org/10.1007/s10549-018-5028-z
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DOI: https://doi.org/10.1007/s10549-018-5028-z