Breast Cancer Research and Treatment

, Volume 173, Issue 1, pp 111–122 | Cite as

Isolated ipsilateral local recurrence of breast cancer: predictive factors and prognostic impact

  • Gilles HouvenaeghelEmail author
  • Alexandre de Nonneville
  • Monique Cohen
  • Jean-Marc Classe
  • Fabien Reyal
  • Chafika Mazouni
  • Nicolas Chopin
  • Alejandra Martinez
  • Emile Daraï
  • Charles Coutant
  • Pierre-Emmanuel Colombo
  • Pierre Gimbergues
  • Marie-Pierre Chauvet
  • Anne-Sophie Azuar
  • Roman Rouzier
  • Christine Tunon de Lara
  • Xavier Muracciole
  • Aubert Agostini
  • Anthony Gonçalves
  • Eric Lambaudie
Clinical trial



Tumour features associated with isolated invasive breast cancer (BC) ipsilateral local recurrence (ILR) after breast conservative treatment (BCT) and consequences on overall survival (OS) are still debated. Our objective was to investigate these points.


Patients were retrospectively identified from a cohort of patients who underwent BCT for invasive BC in 16 cancer centres. End-points were ILR rate and OS. The impact of ILR on OS was assessed by multivariate analysis (MVA) for all patients and according to endocrine receptors (ERs) and grade or tumour subtypes.


Of 15,570 patients, ILR rate was 3.1%. Cumulative ILR rates differed according to ERs/grade (ERs+/Grade2: HR 1.42, p = 0.010; ERs+/Grade3: HR 1.41, p = 0.067; ERs−: HR 2.14, p < 0.0001), endocrine therapy (HR 2.05, p < 0.0001) and age < 40-years old (HR 2.28, p = 0.005) in MVA. When MVA was adjusted on tumour subtype, the latter was the only independent factor. OS-after-ILR was significantly different according to ILR-free intervals (HR 4.96 for ILR-free interval between 2 and 5-years and HR 9.00 when < 2-years, in comparison with ≥ 5-years).


ERs/Grade status, lack of endocrine therapy and tumour subtypes predict isolated ILR risk in patients treated with BCT. Short ILR-free-intervals represent a strong pejorative factor for OS. These results may help selecting initial treatment as well as tailoring ILR systemic chemotherapy.


Ipsilateral Local recurrence Breast cancer Survival Prognosis 



Axillary LN dissection


Breast cancer


Breast conservative treatment


Confidence interval


Endocrine receptors


Human epidermal growth factor 2


Hazard ratio




Ipsilateral local recurrence


Ipsilateral local recurrence-free survival


Lymph node


Lympho-vascular invasion


Overall survival


Pathological node status


Regional nodal irradiation


Sentinel lymph node biopsy


Triple negative breast cancer


Author contributions

Study concepts: GH, AN, MC, AG and EL. Study design: GH, AN, MC, AG and EL. Data acquisition: GH, AN, MC, JMC, FR, CM, NC, AM, ED, CC, PEC, PG, MPC, PA, RR, CTL, XM, AA, AG and EL. Quality control of data and algorithms: GH, AN, MC, JMC, FR, CM, NC, AM, ED, CC, PEC, PG, MPC, PA, RR, CTL, XM, AA, AG and EL. Data analysis and interpretation: GH, AN, MC, JMC, FR, CM, NC, AM, ED, CC, PEC, PG, MPC, PA, RR, CTL, XM, AA, AG and EL. Statistical analysis: GH and EL. Manuscript preparation: GH, AN, MC, AG and EL. Manuscript editing: GH, AN, MC, AG and EL. Manuscript review: GH, AN, MC, JMC, FR, CM, NC, AM, ED, CC, PEC, PG, MPC, PA, RR, CTL, XM, AA, AG and EL.


This research did not receive any specific grant from funding agencies in the public. commercial. or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest to disclose.

Ethical approval

This work was approved by our institutional review board (IPC—Comité d’Orientation Stratégique). All procedures performed in this study involving human participants were done in accordance with the French ethical standards and with the 2008 Helsinki declaration.

Informed consent

All included patients provided written informed consent before surgery.

Supplementary material

10549_2018_4944_MOESM1_ESM.tif (504 kb)
Supplementary material 1 (TIF 504 KB)
10549_2018_4944_MOESM2_ESM.docx (44 kb)
Supplementary material 2 (DOCX 43 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Gilles Houvenaeghel
    • 1
    Email author
  • Alexandre de Nonneville
    • 2
  • Monique Cohen
    • 1
  • Jean-Marc Classe
    • 3
  • Fabien Reyal
    • 4
  • Chafika Mazouni
    • 5
  • Nicolas Chopin
    • 6
  • Alejandra Martinez
    • 7
  • Emile Daraï
    • 8
  • Charles Coutant
    • 9
  • Pierre-Emmanuel Colombo
    • 10
  • Pierre Gimbergues
    • 11
  • Marie-Pierre Chauvet
    • 12
  • Anne-Sophie Azuar
    • 13
  • Roman Rouzier
    • 14
  • Christine Tunon de Lara
    • 15
  • Xavier Muracciole
    • 16
  • Aubert Agostini
    • 17
  • Anthony Gonçalves
    • 2
  • Eric Lambaudie
    • 1
  1. 1.Department of Surgical Oncology, CRCM, Institut Paoli-CalmettesAix-Marseille Univ, CNRS, INSERMMarseilleFrance
  2. 2.Department of Medical Oncology, CRCM, Institut Paoli-CalmettesAix-Marseille Univ, CNRS, INSERMMarseilleFrance
  3. 3.Institut René Gauducheau, Site Hospitalier NordSt HerblainFrance
  4. 4.Institut CurieParis Cedex 05France
  5. 5.Institut Gustave RoussyVillejuifFrance
  6. 6.Centre Léon BérardLyonFrance
  7. 7.Centre Claudius RegaudToulouseFrance
  8. 8.Hôpital TenonParisFrance
  9. 9.Centre Georges François LeclercDijonFrance
  10. 10.Centre Val d’AurellesMontpellier Cedex 5France
  11. 11.Centre Jean PerrinClermont FerrandFrance
  12. 12.Centre Oscar LambretLilleFrance
  13. 13.Hôpital de GrasseGrasseFrance
  14. 14.Hôpital René HugueninSaint CloudFrance
  15. 15.Institut BergoniéBordeauxFrance
  16. 16.Hôpital de la TimoneMarseilleFrance
  17. 17.Hôpital de la Conception, Service de Gynécologie ObstétriqueMarseilleFrance

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