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Breast Cancer Research and Treatment

, Volume 170, Issue 2, pp 405–414 | Cite as

Breast cancer survival, survival disparities, and guideline-based treatment

  • Deirdre A. Hill
  • Sarah Friend
  • Lesley Lomo
  • Charles Wiggins
  • Marc Barry
  • Eric Prossnitz
  • Melanie Royce
Epidemiology
  • 255 Downloads

Abstract

Purpose

The role of appropriate therapy in breast cancer survival and survival disparities by race/ethnicity has not been fully elucidated. We investigated whether lack of guideline-recommended therapy contributed to survival differences overall and among Hispanics relative to non-Hispanic white (NHW) women in a case-cohort study.

Methods

The study included a 15% random sample of female invasive breast cancer patients diagnosed from 1997 to 2009 in 6 New Mexico counties and all deaths due to breast cancer-related causes. Information was obtained from comprehensive medical chart reviews. National Comprehensive Cancer Network (NCCN®) guideline-recommended treatment was assessed among white women aged < 70 who were free of contraindications for recommended therapy, had stage I–III tumors, and survived ≥ 12 months. Hazard ratios (HRs) and 95% confidence intervals (CIs) for breast cancer death were estimated using Cox proportional hazards models.

Results

Included women represented 4635 patients and 449 breast cancer deaths. Women who did not receive radiotherapy (HR 2.3; 95% CI 1.2–4.4) or endocrine therapy (HR 2.0; 95% CI 1.0–4.0) as recommended by guidelines had an increased risk of breast cancer death, relative to those treated appropriately. Receipt of guideline-recommended therapy did not differ between Hispanic and NHW women for chemotherapy (84.2% vs. 81.3%, respectively), radiotherapy (89.2% vs. 91.1%), or endocrine therapy (89.2% vs. 85.8%), thus did not influence Hispanic survival disparities.

Conclusions

Lack of guideline-recommended radiotherapy or endocrine therapy contributed to survival as strongly as other established prognostic indicators. Hispanic survival disparities in this population do not appear to be attributable to treatment differences.

Keywords

Breast neoplasms Guideline adherence Hispanic americans Healthcare disparities Survival analysis 

Notes

Acknowledgements

We would like to thank Ms. Kimberly Cooke, Mr. Nicolas Eldredge, Ms. Rebecca Sando, Ms. Chanel Jim, Mr. Francisco Martinez, Ms. Nancy Brito, and Ms. Georgia Hufnagel for their assistance in conducting this study.

Funding

This study was supported by Grants R01CA132877 and 2P30CA11810 from the National Cancer Institute (NCI) and NCI contract HSN26120130010I-Task Order HHSN26100005 to the Surveillance Epidemiology End Results (SEER) program.

Compliance with ethical standards

Conflict of interest

The authors declare that they do not have any conflict of interest in connection with this manuscript.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Internal Medicine DepartmentUniversity of New Mexico School of MedicineAlbuquerqueUSA
  2. 2.Comprehensive Cancer CenterUniversity of New MexicoAlbuquerqueUSA
  3. 3.Department of Hematology/OncologyEmory University School of MedicineAtlantaUSA
  4. 4.Department of PathologyUniversity of New MexicoAlbuquerqueUSA

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