Health-related quality of life of Iranian breast cancer patients: a meta-analysis and systematic review

  • Salehoddin Bouya
  • Maryam koochakzai
  • Hosein Rafiemanesh
  • Abbas Balouchi
  • Safiyeh Taheri
  • Mahin Badakhsh
  • Mahnaz Didehvar



Quality of life is the most important psychological factor affecting breast cancer patients. This study aimed to examine the health related quality of life of breast cancer patients in Iran.


International (PubMed, Web of science, Scopus and Google scholar) and national (SID, Magiran) databases were searched for related studies to September 2017. The quality of the articles was evaluated using the Hoy tool.


Out of 232 initial studies, 18 studies performed on 2263 people were included in the final stage of the study. Based on the EORTC-QLQ-C30 and random effect method, the pooled mean score of quality of life in 1073 people was 57.88 (95% CI 48.26–67.41, I2 = 97.90%) and the pooled mean score of quality of life based on WHOQOL-BREF in 357 people was 66.79 (95% CI 45.96–87.62, I2 = 99.50%).


According to the results of the study, a moderate level of quality of life in women with breast cancer was indicated. Therefore, the use of multidimensional approaches can improve their quality of life.


Quality of life Breast Cancer Iran Systematic review 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in the study described in this manuscript were in accordance with the ethical standards of the institutional and/or national research committee.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Clinical Immunology Research CenterAli-ebne Abitaleb Hospital, Zahedan University of Medical SciencesZahedanIran
  2. 2.Department of Midwifery, School of Nursing and MidwiferyZabol University of Medical ScienceZabolIran
  3. 3.Student Research Committee, School of Public HealthShahid Beheshti University of Medical SciencesTehranIran
  4. 4.Department of Epidemiology, School of Public HealthShahid Beheshti University of Medical SciencesTehranIran
  5. 5.Zabol University of Medical SciencesZabolIran
  6. 6.Student Research Committee, Nursing and Midwifery SchoolUniversity of Medical SciencesTehranIran
  7. 7.Midwifery Department, School of Nursing and MidwiferyIranshahr University of Medical SciencesIranshahrIran

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