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Breast Cancer Research and Treatment

, Volume 168, Issue 3, pp 649–654 | Cite as

Observation versus excision of lobular neoplasia on core needle biopsy of the breast

  • Hank SchmidtEmail author
  • Brittany Arditi
  • Margaux Wooster
  • Christina Weltz
  • Laurie Margolies
  • Ira Bleiweiss
  • Elisa Port
  • Shabnam Jaffer
Clinical trial

Abstract

Purpose

Controversy surrounds management of lobular neoplasia (LN), [atypical lobular hyperplasia (ALH) or lobular carcinoma in situ (LCIS)], diagnosed on core needle biopsy (CNB). Retrospective series of pure ALH and LCIS reported “upgrade” rate to DCIS or invasive cancer in 0–40%. Few reports document radiologic/pathologic correlation to exclude cases of discordance that are the likely source of most upgrades, and there is minimal data on outcomes with follow-up imaging and clinical surveillance.

Methods

Cases of LN alone on CNB (2001–2014) were reviewed. CNB yielding LN with other pathologic findings for which surgery was indicated were excluded. All patients had either surgical excision or clinical follow-up with breast imaging. All cases included were subject to radiologic–pathologic correlation after biopsy.

Results

178 cases were identified out of 62213 (0.3%). 115 (65%) patients underwent surgery, and 54 (30%) patients had surveillance for > 12 months (mean = 55 months). Of the patients who underwent surgical excision, 13/115 (11%) were malignant. Eight of these 13 found malignancy at excision when CNB results were considered discordant (5 DCIS, and 3 invasive lobular carcinoma), with the remainder, 5/115 (4%), having a true pathologic upgrade: 3 DCIS, and 2 microinvasive lobular carcinoma. Among 54 patients not having excision, 12/54 (22%) underwent subsequent CNB with only 1 carcinoma found at the initial biopsy site.

Conclusions

Surgical excision of LN yields a low upgrade rate when careful consideration is given to radiologic/pathologic correlation to exclude cases of discordance. Observation with interval breast imaging is a reasonable alternative for most cases.

Keywords

Lobular neoplasia Lobular carcinoma in situ Atypical lobular hyperplasia 

Notes

Compliance with ethical standards

Conflict of interest

The research reported in this manuscript complies with the current laws of the United States. The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of SurgeryIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Dubin Breast Center of the Tisch Cancer InstituteNew YorkUSA
  3. 3.Department of RadiologyIcahn School of Medicine at Mount SinaiNew YorkUSA
  4. 4.Department of PathologyUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaUSA
  5. 5.Department of PathologyIcahn School of Medicine at Mount SinaiNew YorkUSA

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