Predictors of survival for breast cancer patients with a BRCA1 mutation

Abstract

Purpose

To evaluate in a contemporary cohort the impacts of chemotherapy and oophorectomy on survival for breast cancer patients with a BRCA1 mutation.

Experimental design

We reviewed the pathology reports and medical records of 372 women with breast cancer and a BRCA1 mutation, diagnosed from 2005 to 2017, between the ages of 25 and 65 and followed them for death from all causes and death from breast cancer. Death was ascertained through the Poland vital statistics registry. We performed survival analysis to evaluate the impacts of chemotherapy (including neoadjuvant cisplatinum) and of oophorectomy on survival.

Results

After a mean follow-up of 5.6 years (median 5.2), 66 of the 372 women died; 56 of the deaths were from breast cancer and 6 were from ovarian cancer. 127 women received neoadjuvant cisplatinum and 245 women received other chemotherapies. Cisplatinum (versus all other therapies) was associated with a hazard ratio of 0.42 (95%CI 0.20–0.87) on breast cancer-specific survival. The 10-year actuarial all-cause survival for women who had both cisplatinum and an oophorectomy was 94.4%. The 10-year all-cause survival for women who had neither cisplatinum nor an oophorectomy was 65.4% (p < 0.01).

Conclusions

Cisplatinum and oophorectomy are effective therapies for women with breast cancer and a BRCA1 mutation.

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Acknowledgements

We thank Ewa Putresza for excellent technical support. We thank the Peter Gilgan Foundation Tour de Bleu and Estée Lauder Companies for their generous support of this project.

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Correspondence to Steven A. Narod.

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The authors have no conflicts of interest to declare.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Narod, S.A., Huzarski, T., Gronwald, J. et al. Predictors of survival for breast cancer patients with a BRCA1 mutation. Breast Cancer Res Treat 168, 513–521 (2018). https://doi.org/10.1007/s10549-017-4605-x

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Keywords

  • BRCA1
  • Breast cancer
  • Survival
  • Cisplatinum
  • Oophorectomy