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Characteristics and prognosis of breast cancer after liver or kidney transplantation

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Abstract

Purpose

Immunoediting is crucial in cancer development and progression. This study compared the characteristics and prognosis of post-transplant breast cancer (PTBC) patients receiving immunosuppressants and general breast cancer patients.

Methods

Data from the Asan Medical Center Breast Cancer (AMCBC), kidney transplantation, and liver transplantation databases recorded during 1989–2013 were retrospectively analyzed. Four controls of AMCBC cohort per one case of PTBC cohort were selected based on tumor size, lymph node metastasis, and age.

Results

After a median of 61 and 90.8 months after liver and kidney transplantation, respectively, 8 and 16 patients were diagnosed with breast cancer, respectively (p = 0.178). Mean age at breast cancer diagnosis was 51.9 (±8.7) and 45.2 (±4.5) years in liver and kidney transplantation patients, respectively. Age at diagnosis was significantly younger in kidney transplantation patients than in general breast cancer patients (45.2 ± 4.5 vs. 48.5 ± 10.1 years; p = 0.008). Cancer was detected via asymptomatic screening in 41.7% of the PTBC cohort but 30.6% of the control cohort (p = 0.241). In the PTBC cohort, 7 (29.2%) patients had stage 0 breast cancer compared with 1704 (9.7%) in the control cohort (p = 0.022); 22 (91.7%) patients had lymph node-negative cancer compared with 11,704 (66.8%) in the control cohort (p = 0.01). Estrogen receptor, progesterone receptor, and HER2 positivity did not differ between cohorts. Immunosuppressant use was not a poor prognostic factor for breast cancer patients.

Conclusions

Age at breast cancer diagnosis was younger in patients who received kidney transplants; the subtype and prognosis of breast cancer were comparable with that in the general cohort. Immunosuppressants do not adversely affect breast cancer prognosis.

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Authors and Affiliations

  1. Division of Breast and Endocrine Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, 388-1, Pungnap-2dong, Song pa Gu, Seoul, 05505, Korea

    Beom Seok Ko, Jong Won Lee, Byung Ho Son, Se-Hyun Ahn & Hee Jeong Kim

  2. Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Korea

    I-Ji Jeong & Young Hoon Kim

  3. Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Korea

    Sung-Gyu Lee

Authors
  1. I-Ji Jeong
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  2. Sung-Gyu Lee
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  3. Young Hoon Kim
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  4. Beom Seok Ko
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  5. Jong Won Lee
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  7. Se-Hyun Ahn
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Correspondence to Hee Jeong Kim.

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Jeong, IJ., Lee, SG., Kim, Y.H. et al. Characteristics and prognosis of breast cancer after liver or kidney transplantation. Breast Cancer Res Treat 167, 101–106 (2018). https://doi.org/10.1007/s10549-017-4504-1

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  • DOI: https://doi.org/10.1007/s10549-017-4504-1

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