Lifetime moderate-to-vigorous physical activity and ER/PR/HER-defined post-menopausal breast cancer risk
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To assess the relationship of moderate-to-vigorous physical activity (MVPA) in leisure-time, household, and occupational domains across the total lifetime and in four age periods with breast cancer risk, as defined by estrogen receptor (ER)/progesterone receptor (PR) status and ER/PR/human epidermal growth factor-2 (HER2) status, among post-menopausal women.
Data were from 692 women with incident breast cancer and 644 controls in the Canadian Breast Cancer Study, a case–control study of women aged 40–80 years in British Columbia and Ontario. Mean metabolic equivalent (MET)-hours/week for questionnaire-assessed leisure-time, household, and occupational MVPA were calculated for the total lifetime and four age periods (12–17, 18–34, 45–49, and ≥50 years). Odds ratios (ORs) for the relationships between domain-specific MVPA at each lifetime period and risks of ER/PR-defined and ER/PR/HER2-defined breast cancers were estimated using polytomous logistic regression. Trend tests for dose–response relationships were calculated for the ORs across increasing tertiles of mean MET-hours/week of MVPA.
Total lifetime leisure-time MVPA was associated with reduced risk of ER−/PR− breast cancer in a dose–response fashion (ptrend = 0.014). In contrast, total lifetime household MVPA was associated with reduced risk of ER+ and/or PR+ breast cancer (ptrend < 0.001). When further stratified by HER2 status, the effect of leisure-time MVPA appeared confined to HER2− breast cancers, and the effect of household MVPA did not differ according to HER2 status. Similar trends were observed when stratified by age period.
Lifetime leisure-time MVPA appeared to be associated with reduced risk of ER−/PR−/HER2− breast cancers and lifetime household MVPA was associated with reduced risk of ER+ and/or PR+ breast cancer, regardless of HER2 status.
KeywordsPhysical activity Breast cancer Estrogen Progesterone HER2
- 2.Boyle P (2012) Triple-negative breast cancer: epidemiological considerations and recommendations. Ann Oncol 23:vi7–vi12. doi:10.1093/annonc/mds187
- 6.Parise CA, Bauer KR, Brown MM, Caggiano V (2009) Breast cancer subtypes as defined by the estrogen receptor (ER), progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER2) among women with invasive breast cancer in California, 1999-2004. Breast J 15:593–602. doi:10.1111/j.1524-4741.2009.00822.x CrossRefPubMedGoogle Scholar
- 14.Enger SM, Ross RK, Paganini-hill A, Carpenter CL, Bernstein L (2000) Body size, physical activity, and breast cancer hormone receptor status: results from two case-control studies. Cancer Epidemiol Biomark Prev 9:681–687Google Scholar
- 18.Schmidt ME, Steindorf K, Mutschelknauss E, Slanger T, Kropp S, Obi N et al (2008) Physical activity and postmenopausal breast cancer: effect modification by breast cancer subtypes and effective periods in life. Cancer Epidemiol Biomark Prev 17:3402–3410. doi:10.1158/1055-9965.EPI-08-0479 CrossRefGoogle Scholar
- 23.Steindorf K, Ritte R, Eomois P, Lukanova A, Tjonneland A, Johnsen N et al (2012) Physical activity and risk of breast cancer overall and by hormone receptor status: the European prospective investigation into cancer and nutrition. Int J Cancer 132:1667–1678. doi:10.1002/ijc.27778 CrossRefPubMedGoogle Scholar
- 34.Friedenreich CM (2011) Physical activity and breast cancer: review of the epidemiologic evidence and biological mechanisms. In: Senn H-J, Otto F (eds) Clinical cancer prevention. Springer, Berlin, pp 125–139Google Scholar
- 36.Friedenreich C, Woolcott C, McTiernan A, Ballard-Barbash R, Brant R, Stanczyk F et al (2010) Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J Clin Oncol 28:1458–1466. doi:10.1200/JCO.2009.24.9557 CrossRefPubMedPubMedCentralGoogle Scholar
- 38.Lynch BM, Friedenreich CM, Vallance JK, Eakin EG, Owen N (2011) Associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from NHANES (2003–2006). Breast Cancer Res Treat 130:183–194. doi:10.1007/s10549-011-1559-2 CrossRefPubMedGoogle Scholar
- 40.Friedenreich CM, Neilson HK, Woolcott CG, Mctiernan A, Wang Q, Ballard-Barbash R et al (2011) Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocr Relat Cancer 18:357–369. doi:10.1530/ERC-10-0303 CrossRefPubMedPubMedCentralGoogle Scholar
- 46.McTiernan A, Sorensen B, Yasui Y, Tworoger SS, Ulrich CM, Irwin ML et al (2005) No effect of exercise on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in postmenopausal women: a 12-month randomized clinical trial. Cancer Epidemiol Biomark Prev 14:1020–1021CrossRefGoogle Scholar