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Table 1 Frequencies of a low-risk and a high-risk OncotypeDX (ODX) recurrence score with commercial cut-off values and pathologic descriptive characteristics

From: Oncotype DX breast cancer recurrence score can be predicted with a novel nomogram using clinicopathologic data

Characteristics No Original cohort
NCDB 2010-2012 Commercial cut-off values
No Validation cohort NCDB 2013
Commercial cut-off values
p value
No of patients ODX
Low risk (0–17)
No
(% total)
ODX
High risk (31–100)
No
(% total)
ODX
Low risk (0–17)
No
(% total)
ODX
High risk (31–100)
No
(% total)
 
Sex—female 27,685 23,937 (86.5) 3748 (13.5) 12763 11,185 (87.6) 1578 (12.4)  
Age (20–90) (mean ± SD) 27,685
58.43 ± 10.3
23,937 (86.5) 3748 (13.5) 12763
59.04 ± 10.3
11,185 (87.6) 1578 (12.4) <.001
 ≤40 1055 837 (3.0) 218 (0.8) 440 338 (2.6) 102 (0.8)  
 41–69 22,623 19728 (71.3) 2895 (10.5) 10251 9056
(71)
1195 (9.4)  
 ≥70 4007 3372 (12.2) 635 (2.3) 2072 1791 (14) 281 (2.2)  
Tumor size (6–50 mm) Mean ± SD 27,685
16.18 ± 7.7
23,937 (86.5) 3748 (13.5) 12,763
16.02 ± 7.7
11,185 (87.6) 1578 (12.4) .044
 T1b 6581 5972 (21.6) 609 (2.2) 3197 2948 (23.1) 249 (2.0)  
 T1c 14,961 13105 (47.3) 1856 (6.7) 6772 6009 (47.1) 763 (6.0)  
 T2 6143 4860 (17.6) 1283 (4.6) 2794 2228 (17.5) 566 (4.4)  
Histologic type 27,685 23937 (86.5) 3748 (13.5) 12,763 11185 (87.6) 1578 (12.4) >.05
 IDC 21,664 18235 (65.9) 3429 (12.4) 9931 8509 (66.7) 1422 (11.1)  
 ILC 3023 2896 (10.5) 127 (0.5) 1466 1405 (11.0) 61 (0.5)  
 IDC + ILC 1926 1831 (6.6) 95 (0.3) 897 853 (6.7) 44 (0.3)  
 IDC + others 1072 975 (3.5) 97 (0.4) 469 418 (3.3) 51 (0.4)  
Histologic grade 27,685 23937 (86.5) 3748 (13.5) 12,763 11185 (87.6) 1578 (12.4) .30
 Grade 1 8516 8349 (30.2) 167 (0.6) 3955 3887 (30.5) 68 (0.5)  
 Grade 2 14,906 13636 (49.3) 1270 (4.6) 6947 6438 (50.4) 509 (4.0)  
 Grade 3 4263 1962 (7.1) 2311 (8.3) 1861 860 (6.7) 1001 (7.8)  
LVI 27685 23937 (86.5) 3748 (13.5) 12763 11185 (87.6) 1578 (12.4) .98
 Not present 24,885 21767 (78.6) 3118 (11.3) 11,471 10171 (79.7) 1300 (10.2)  
 Present 2800 2170 (7.8) 630 (2.3) 1292 1014 (7.9) 278 (2.2)  
Progesterone receptor 27,685 23937 (86.5) 3748 (13.5) 12,763 11185 (87.6) 1578 (12.4) .005
 Positive 25,419 23128 (83.5) 2291 (8.3) 11,821 10821 (84.8) 1000 (7.8)  
 Negative 2266 809 (2.9) 1457 (5.3) 942 364 (2.9) 578 (4.5)  
  1. SD standard deviation, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, IDC + ILC invasive ductal and lobular carcinoma, IDC + others invasive ductal carcinoma mixed with other types, LVI lymph-vascular invasion