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Breast Cancer Research and Treatment

, Volume 158, Issue 1, pp 113–126 | Cite as

Breast cancers from black women exhibit higher numbers of immunosuppressive macrophages with proliferative activity and of crown-like structures associated with lower survival compared to non-black Latinas and Caucasians

  • Tulay Koru-Sengul
  • Ana M. Santander
  • Feng Miao
  • Lidia G. Sanchez
  • Merce Jorda
  • Stefan Glück
  • Tan A. Ince
  • Mehrad Nadji
  • Zhibin Chen
  • Manuel L Penichet
  • Margot P. Cleary
  • Marta Torroella-KouriEmail author
Epidemiology

Abstract

Racial disparities in breast cancer incidence and outcome are a major health care challenge. Patients in the black race group more likely present with an early onset and more aggressive disease. The occurrence of high numbers of macrophages is associated with tumor progression and poor prognosis in solid malignancies. Macrophages are observed in adipose tissues surrounding dead adipocytes in “crown-like structures” (CLS). Here we investigated whether the numbers of CD163+ tumor-associated macrophages (TAMs) and/or CD163+ CLS are associated with patient survival and whether there are significant differences across blacks, non-black Latinas, and Caucasians. Our findings confirm that race is statistically significantly associated with the numbers of TAMs and CLS in breast cancer, and demonstrate that the highest numbers of CD163+ TAM/CLS are found in black breast cancer patients. Our results reveal that the density of CD206 (M2) macrophages is a significant predictor of progression-free survival univariately and is also significant after adjusting for race and for HER2, respectively. We examined whether the high numbers of TAMs detected in tumors from black women were associated with macrophage proliferation, using the Ki-67 nuclear proliferation marker. Our results reveal that TAMs actively divide when in contact with tumor cells. There is a higher ratio of proliferating macrophages in tumors from black patients. These findings suggest that interventions based on targeting TAMs may not only benefit breast cancer patients in general but also serve as an approach to remedy racial disparity resulting in better prognosis patients from minority racial groups.

Keywords

Breast cancer Race/ethnicities Macrophages Crown-like structures Inflammation 

Notes

Acknowledgments

We would like to extend our thanks to the University of Miami Sylvester Comprehensive Cancer Center’s Tissue Bank Core Facility and the Tumor Registry, and particularly to Drs. Consuelo Alvarez and Clara Milikowski without whom this investigation would not have been carried out. This study was funded by the Braman Family Breast Cancer Institute Development Grant from Sylvester Comprehensive Cancer Center at University of Miami Miller School of Medicine and also in part by the NCI/NIH R21CA176055 both to MTK. Research for this article was supported in part by funding to T.A.I from Breast Cancer Research Foundation and Play for P.I.N.K., NIEHS R01-ES024991, Women’s Cancer Association of UM and Sylvester Comprehensive Cancer Center; to L.G.S from a supplement to R21CA176055, to ZC from R21CA178675; to MLP from R01CA181115 and to M.P.C. from R01CA157012.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10549_2016_3847_MOESM1_ESM.pdf (384 kb)
Supplementary material 1 (PDF 384 kb)

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Tulay Koru-Sengul
    • 1
    • 5
  • Ana M. Santander
    • 2
  • Feng Miao
    • 5
  • Lidia G. Sanchez
    • 2
  • Merce Jorda
    • 3
    • 5
  • Stefan Glück
    • 4
    • 5
    • 12
  • Tan A. Ince
    • 3
    • 5
  • Mehrad Nadji
    • 3
    • 5
  • Zhibin Chen
    • 2
    • 5
  • Manuel L Penichet
    • 6
    • 7
    • 8
    • 9
    • 10
  • Margot P. Cleary
    • 11
  • Marta Torroella-Kouri
    • 2
    • 1
    • 5
    Email author
  1. 1.Department of Public Health SciencesUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of Miami Miller School of MedicineMiamiUSA
  3. 3.Department of PathologyUniversity of Miami Miller School of MedicineMiamiUSA
  4. 4.Department of MedicineUniversity of Miami Miller School of MedicineMiamiUSA
  5. 5.Sylvester Comprehensive Cancer CenterUniversity of Miami Miller School of MedicineMiamiUSA
  6. 6.Division of Surgical Oncology, Department of SurgeryUCLALos AngelesUSA
  7. 7.Department of Microbiology, Immunology, and Molecular GeneticsDavid Geffen School of Medicine at UCLA, UCLALos AngelesUSA
  8. 8.Jonsson Comprehensive Cancer Center, UCLALos AngelesUSA
  9. 9.UCLA AIDS Institute, UCLALos AngelesUSA
  10. 10.The Molecular Biology Institute, UCLALos AngelesUSA
  11. 11.Hormel Institute, University of MinnesotaAustinUSA
  12. 12.Celgene CorporationSummitUSA

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