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Serum 25-hydroxyvitamin D deficiency and increased risk of breast cancer among Korean women: a case–control study

Breast Cancer Research and Treatment volume 152, pages 147–154 (2015)Cite this article

Abstract

Despite the emerging literature supporting the beneficial role of vitamin D on various health outcomes including carcinogenesis, current evidence on the association between vitamin D and breast cancer is still largely inconsistent. Furthermore, this relationship is particularly under explored among Asian population. We conducted a large case–control study with Korean women. We obtained and compared serum 25-hydroxyvitamin D (25(OH)D) between breast cancer patients (N = 3634) and general population (N = 17,133). Moreover, we further examined the association between serum 25(OH)D and breast cancer risk stratified by menopausal status and hormone receptor (HR) status of the tumor. Adjusted odds ratio (OR) for breast cancer comparing women with deficient level of serum 25(OH)D to women with sufficient level of serum 25(OH)D was 1.27 [95 % confidence interval (CI) 1.15–1.39]. This association did not significantly vary by menopausal status [pre-menopause: 1.26 (95 % CI 1.09–1.45) vs. post-menopause: 1.25 (95 % CI 1.10–1.41)]. When stratified by HR status, the inverse association remained significant in both positive and negative statuses. However, this association was more pronounced in HR-negative breast cancer, particularly with triple-negative breast cancer patients (1.45, 95 % CI 1.15–1.82). Given the growing burden of breast cancer in Asia and dearth of studies examining the association between vitamin D and breast cancer risk in Asian women thus far, this study provides a meaningful evidence for potential preventive effect of vitamin D on breast cancer for this particular population.

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    Authors and Affiliations

    1. Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea

      Seho Park, Jegyu Ryu, Sanghwa Kim, Jee Ye Kim, Hyung Seok Park, Seung Il Kim & Byeong-Woo Park

    2. Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Boston, United States

      Dong Hoon Lee

    3. Department of Sport and Leisure Studies, Exercise Medicine Center for Diabetes and Cancer Patients (ICONS), Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-749, South Korea

      Justin Y. Jeon

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    1. Seho Park
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    Correspondence to Justin Y. Jeon or Seung Il Kim.

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    Seho Park and Dong Hoon Lee have contributed equally to this work.

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    Park, S., Lee, D.H., Jeon, J.Y. et al. Serum 25-hydroxyvitamin D deficiency and increased risk of breast cancer among Korean women: a case–control study. Breast Cancer Res Treat 152, 147–154 (2015). https://doi.org/10.1007/s10549-015-3433-0

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    • DOI: https://doi.org/10.1007/s10549-015-3433-0

    Keywords

    • Vitamin D
    • 25-Hydroxyvitamin D
    • Breast cancer
    • Menopausal status
    • Hormone receptor