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Greater absolute risk for all subtypes of breast cancer in the US than Malaysia

  • Epidemiology
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Abstract

Hormone receptor (HR) negative breast cancers are relatively more common in low-risk than high-risk countries and/or populations. However, the absolute variations between these different populations are not well established given the limited number of cancer registries with incidence rate data by breast cancer subtype. We, therefore, used two unique population-based resources with molecular data to compare incidence rates for the ‘intrinsic’ breast cancer subtypes between a low-risk Asian population in Malaysia and high-risk non-Hispanic white population in the National Cancer Institute’s surveillance, epidemiology, and end results 18 registries database (SEER 18). The intrinsic breast cancer subtypes were recapitulated with the joint expression of the HRs (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor-2 (HER2). Invasive breast cancer incidence rates overall were fivefold greater in SEER 18 than in Malaysia. The majority of breast cancers were HR-positive in SEER 18 and HR-negative in Malaysia. Notwithstanding the greater relative distribution for HR-negative cancers in Malaysia, there was a greater absolute risk for all subtypes in SEER 18; incidence rates were nearly 7-fold higher for HR-positive and 2-fold higher for HR-negative cancers in SEER 18. Despite the well-established relative breast cancer differences between low-risk and high-risk countries and/or populations, there was a greater absolute risk for HR-positive and HR-negative subtypes in the US than Malaysia. Additional analytical studies are sorely needed to determine the factors responsible for the elevated risk of all subtypes of breast cancer in high-risk countries like the United States.

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References

  1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. doi:10.1002/ijc.25516

    Google Scholar 

  2. Kamangar F, Dores GM, Anderson WF (2006) Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer rates in different geographic regions of the world. J Clin Oncol 24(14):2137–2150

    Article  PubMed  Google Scholar 

  3. Bray F, Jemal A, Grey N, Ferlay J, Forman D (2012) Global cancer transitions according to the human development index (2008-2030): a population-based study. Lancet Oncology 13(8):790–801. doi:10.1016/S1470-2045(12)70211-5

    Article  Google Scholar 

  4. Huo D, Ikpatt F, Khramtsov A, Dangou JM, Nanda R, Dignam J, Zhang B, Grushko T, Zhang C, Oluwasola O, Malaka D, Malami S, Odetunde A, Adeoye AO, Iyare F, Falusi A, Perou CM, Olopade OI (2009) Population differences in breast cancer: survey in indigenous African women reveals over-representation of triple-negative breast cancer. J Clin Oncol 27(27):4515–4521. doi:10.1200/JCO.2008.19.6873

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Bhikoo R, Srinivasa S, Yu TC, Moss D, Hill AG (2011) Systematic review of breast cancer biology in developing countries (part 1): Africa, the middle East, Eastern Europe, Mexico, the Caribbean and South America. Cancers 3(2):2358–2381. doi:10.3390/cancers3022358

    Article  PubMed Central  PubMed  Google Scholar 

  6. Bhikoo R, Srinivasa S, Yu TC, Moss D, Hill AG (2011) Systematic review of breast cancer biology in developing countries (part 2): Asian subcontinent and South East Asia. Cancers 3(2):2382–2401. doi:10.3390/cancers3022382

    Article  PubMed Central  PubMed  Google Scholar 

  7. Howlader N, Altekruse SF, Li CI, Chen VW, Clarke CA, Ries LAG, Cronin KA (2014) US Incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status. J Natl Cancer Inst 106(5):dju055

    Article  PubMed  Google Scholar 

  8. SEER-18 (2014) Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases, Nov 2013 Sub (2000-2011) < Katrina/Rita Population Adjustment > - Linked To County Attributes - Total U.S., 1969-2012 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2014 (updated 5/7/2014), based on the November 2013 submission. www.seer.cancer.gov

  9. Devi CR, Tang TS, Corbex M (2012) Incidence and risk factors for breast cancer subtypes in three distinct South-East Asian ethnic groups: Chinese, Malay and natives of Sarawak. Malaysia. Int J Cancer 131(12):2869–2877. doi:10.1002/ijc.27527

    Article  CAS  Google Scholar 

  10. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D (2000) Molecular portraits of human breast tumours. Nature 406(6797):747–752

    Article  CAS  PubMed  Google Scholar 

  11. Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lonning PE, Brown PO, Borresen-Dale AL, Botstein D (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 100(14):8418–8423

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, Akslen LA, Ragaz J, Gown AM, Gilks CB, van de Rijn M, Perou CM (2004) Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 10(16):5367–5374

    Article  CAS  PubMed  Google Scholar 

  13. Clarke CA, Keegan TH, Yang J, Press DJ, Kurian AW, Patel AH, Lacey JV Jr (2012) Age-specific incidence of breast cancer subtypes: understanding the black-white crossover. J Natl Cancer Inst 104(14):1094–1101. doi:10.1093/jnci/djs264

    Article  PubMed Central  PubMed  Google Scholar 

  14. Anderson WF, Katki HA, Rosenberg PS (2011) Breast cancer incidence in the United States: current and future trends. J Natl Cancer Inst 103(18):1397–1402. doi:10.1093/jnci/djr257

    Article  PubMed Central  PubMed  Google Scholar 

  15. Gomez SL, Quach T, Horn-Ross PL, Pham JT, Cockburn M, Chang ET, Keegan TH, Glaser SL, Clarke CA (2010) Hidden breast cancer disparities in asian women: disaggregating incidence rates by ethnicity and migrant status. Am J Public Health 100(Suppl 1):S125–S131. doi:10.2105/AJPH.2009.163931

    Article  PubMed Central  PubMed  Google Scholar 

  16. Yau TK, Sze H, Soong IS, Hioe F, Khoo US, Lee AW (2008) HER2 overexpression of breast cancers in Hong Kong: prevalence and concordance between immunohistochemistry and in situ hybridisation assays. Hong Kong Acad Med 14(2):130–135

    CAS  Google Scholar 

  17. Zhao J, Liu H, Wang M, Gu L, Guo X, Gu F, Fu L (2009) Characteristics and prognosis for molecular breast cancer subtypes in Chinese women. J Surg Oncol 100(2):89–94. doi:10.1002/jso.21307

    Article  PubMed  Google Scholar 

  18. Tan YO, Han S, Lu YS, Yip CH, Sunpaweravong P, Jeong J, Caguioa PB, Aggarwal S, Yeoh EM, Moon H (2010) The prevalence and assessment of ErbB2-positive breast cancer in Asia: a literature survey. Cancer 116(23):5348–5357. doi:10.1002/cncr.25476

    Article  PubMed Central  PubMed  Google Scholar 

  19. Ma H, Wang Y, Sullivan-Halley J, Weiss L, Marchbanks PA, Spirtas R, Ursin G, Burkman RT, Simon MS, Malone KE, Strom BL, McDonald JA, Press MF, Bernstein L (2010) Use of four biomarkers to evaluate the risk of breast cancer subtypes in the women’s contraceptive and reproductive experiences study. Cancer Res 70(2):575–587. doi:10.1158/0008-5472.CAN-09-3460

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Bianchini F, Kaaks R, Vainio H (2002) Overweight, obesity, and cancer risk. Lancet Oncol 3(9):565–574

    Article  PubMed  Google Scholar 

  21. Porter PL, El-Bastawissi AY, Mandelson MT, Lin MG, Khalid N, Watney EA, Cousens L, White D, Taplin S, White E (1999) Breast tumor characteristics as predictors of mammographic detection: comparison of interval- and screen-detected cancers. J Natl Cancer Inst 91(23):2020–2028

    Article  CAS  PubMed  Google Scholar 

  22. Palmer JR, Viscidi E, Troester MA, Hong CC, Schedin P, Bethea TN, Bandera EV, Borges V, McKinnon C, Haiman CA, Lunetta K, Kolonel LN, Rosenberg L, Olshan AF, Ambrosone CB (2014) Parity, lactation, and breast cancer subtypes in African American women: results from the AMBER consortium. J Natl Cancer Inst. doi:10.1093/jnci/dju237

    Google Scholar 

  23. McCormack VA, Joffe M, van den Berg E, Broeze N, Silva Idos S, Romieu I, Jacobson JS, Neugut AI, Schuz J, Cubasch H (2013) Breast cancer receptor status and stage at diagnosis in over 1,200 consecutive public hospital patients in Soweto, South Africa: a case series. Breast Cancer Res 15(5):R84. doi:10.1186/bcr3478

    Article  PubMed Central  PubMed  Google Scholar 

  24. Stark A, Kleer CG, Martin I, Awuah B, Nsiah-Asare A, Takyi V, Braman M, Quayson SE, Zarbo R, Wicha M, Newman L (2010) African ancestry and higher prevalence of triple-negative breast cancer: findings from an international study. Cancer 116(21):4926–4932. doi:10.1002/cncr.25276

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to thank the Pathology Department of Sarawak General Hospital and Ms. Rokia Iren for their assistance in tissue block retrieval. Research support Intramural Research Program of the NIH, NCI, DCEG.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA

    Hisani N. Horne, Hyuna Sung, Philip S. Rosenberg, William F. Anderson & Xiaohong R. Yang

  2. Department of Radiotherapy, Oncology and Palliative Care, Sarawak General Hospital, Kuching, Sarawak, Malaysia

    C. R. Beena Devi & Tieng Swee Tang

  3. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Stephen M. Hewitt

  4. Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD, USA

    Mark E. Sherman

  5. National Cancer Institute/DCEG/GEB, National Institutes of Health, 9609 Medical Center Drive Rm 6E426, MSC 9769, Bethesda, MD, 20892-9769, USA

    Xiaohong R. Yang

Authors
  1. Hisani N. Horne
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  2. C. R. Beena Devi
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  3. Hyuna Sung
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  4. Tieng Swee Tang
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  5. Philip S. Rosenberg
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  6. Stephen M. Hewitt
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  7. Mark E. Sherman
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  8. William F. Anderson
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  9. Xiaohong R. Yang
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Corresponding author

Correspondence to Xiaohong R. Yang.

Additional information

William F. Anderson and Xiaohong R. Yang share last authorship.

Hisani N. Horne, C.R. Beena Devi, and Hyuna Sung contributed equally to the work.

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Horne, H.N., Beena Devi, C.R., Sung, H. et al. Greater absolute risk for all subtypes of breast cancer in the US than Malaysia. Breast Cancer Res Treat 149, 285–291 (2015). https://doi.org/10.1007/s10549-014-3243-9

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  • DOI: https://doi.org/10.1007/s10549-014-3243-9

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