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Early myocardial deformation abnormalities in breast cancer survivors

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Abstract

To evaluate the role of 2D myocardial strain (rate) imaging in the detection of early subclinical cardiotoxicity in breast cancer survivors treated with an anthracycline-based chemotherapeutic regimen. 57 adult breast cancer survivors were analyzed 1 year after therapy. All patients underwent biomarker analysis and 2D echocardiography consisting of conventional echocardiographic and strain (rate) parameters. Conventional echocardiographic values were normal. Global longitudinal strain was normal, but 18 % of patients showed a >2 SD decrease when individually compared to reference values. This subgroup showed a decrease in end-systolic and end-diastolic volumes and an increase in left ventricular mass. Radial and circumferential strain rates were significantly decreased in the whole study group. 2D myocardial strain (rate) imaging showed abnormalities in breast cancer survivors, while conventional echocardiographic values remained normal, rendering 2D myocardial strain (rate) imaging an interesting tool for the early detection of anthracycline-induced cardiotoxicity.

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Acknowledgments

We kindly thank Caroline Mandigers and Harald Fliervoet for contributing to the enrollment of patients in our study. This study was financially supported by Cephalon B.V., Merck Sharp & Dohme B.V. and Sanofi-Aventis Netherlands B.V.

Conflict of interest

The study sponsors had no involvement in the study. The authors declare that they have no conflict of interest.

Author information

Author notes

  1. Hanneke W. M. van Laarhoven

    Present address: Department of Medical Oncology, Academic Medical Centre, Meibergdreef 9, Amsterdam, The Netherlands

  2. Livia Kapusta

    Present address: Tel Aviv Sourasky Medical Center, Weizmann Street 10, Tel Aviv, Israel

Authors and Affiliations

  1. Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Geert Grooteplein 10, PO Box 9101 (internal postal code 757), 6500 HB, Nijmegen, The Netherlands

    Ben F. Bulten & Lioe-Fee de Geus-Oei

  2. Department of Pediatric Hematology & Oncology, Radboud University Medical Centre, Geert Grooteplein 10, Nijmegen, The Netherlands

    Annelies M. C. Mavinkurve-Groothuis

  3. Department of Health Evidence Section Biostatistics, Radboud University Medical Centre, Geert Grooteplein 10, Nijmegen, The Netherlands

    Anton F. J. de Haan

  4. Medical Ultrasound Imaging Centre (MUSIC), Radboud University Medical Centre, Geert Grooteplein 10, Nijmegen, The Netherlands

    Chris L. de Korte

  5. Department of Cardiology, Radboud University Medical Centre, Geert Grooteplein 10, Nijmegen, The Netherlands

    Louise Bellersen

  6. Department of Medical Oncology, Radboud University Medical Centre, Geert Grooteplein 10, Nijmegen, The Netherlands

    Hanneke W. M. van Laarhoven

  7. Children’s Heart Centre, Radboud University Medical Centre, Geert Grooteplein 10, Nijmegen, The Netherlands

    Livia Kapusta

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Bulten, B.F., Mavinkurve-Groothuis, A.M.C., de Geus-Oei, LF. et al. Early myocardial deformation abnormalities in breast cancer survivors. Breast Cancer Res Treat 146, 127–135 (2014). https://doi.org/10.1007/s10549-014-2997-4

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