Skip to main content

Breast fat and breast cancer

Breast Cancer Research and Treatment volume 135, pages 321–323 (2012)Cite this article

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Fig. 1

References

  1. Pettersson A, Hankinson SE, Willett WC, Lagiou P, Trichopoulos D, Tamimi RM (2011) Nondense mammographic area and risk of breast cancer. Breast Cancer Res 13(5):R100

    PubMed  Article  Google Scholar 

  2. Byrne C, Schairer C, Wolfe J et al (1995) Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst 87(21):1622–1629

    PubMed  Article  CAS  Google Scholar 

  3. McCormack VA, dos Santos Silva I (2006) Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 15(6):1159–1169

    PubMed  Article  Google Scholar 

  4. Trichopoulos D, Lipman RD (1992) Mammary gland mass and breast cancer risk. Epidemiology 3(6):523–526

    PubMed  Article  CAS  Google Scholar 

  5. Stuedal A, Ma H, Bernstein L, Pike MC, Ursin G (2008) Does breast size modify the association between mammographic density and breast cancer risk? Cancer Epidemiol Biomarkers Prev 17(3):621–627

    PubMed  Article  Google Scholar 

  6. Lokate M, Peeters PH, Peelen LM, Haars G, Veldhuis WB, van Gils CH (2011) Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue. Breast Cancer Res 13(5):R103

    PubMed  Article  CAS  Google Scholar 

  7. Stone J, Ding J, Warren RM, Duffy SW, Hopper JL (2010) Using mammographic density to predict breast cancer risk: dense area or percentage dense area. Breast Cancer Res 12(6):R97

    Google Scholar 

  8. Torres-Mejia G, De Stavola B, Allen DS et al (2005) Mammographic features and subsequent risk of breast cancer: a comparison of qualitative and quantitative evaluations in the Guernsey prospective studies. Cancer Epidemiol Biomarkers Prev 14(5):1052–1059

    PubMed  Article  Google Scholar 

  9. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578

    PubMed  Article  Google Scholar 

  10. Key TJ, Appleby PN, Reeves GK et al (2003) Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 95(16):1218–1226

    PubMed  Article  CAS  Google Scholar 

  11. Rose DP, Vona-Davis L (2010) Interaction between menopausal status and obesity in affecting breast cancer risk. Maturitas 66(1):33–38

    PubMed  Article  Google Scholar 

  12. Boyd NF, Martin LJ, Sun L et al (2006) Body size, mammographic density, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 15(11):2086–2092

    PubMed  Article  Google Scholar 

  13. Harris HR, Tamimi RM, Willett WC, Hankinson SE, Michels KB (2011) Body size across the life course, mammographic density, and risk of breast cancer. Am J Epidemiol 174(8):909–918

    PubMed  Article  Google Scholar 

  14. Hovey RC, Aimo L (2010) Diverse and active roles for adipocytes during mammary gland growth and function. J Mammary Gland Biol Neoplasia 15(3):279–290

    PubMed  Article  Google Scholar 

  15. Ching S, Kashinkunti S, Niehaus MD, Zinser GM (2011) Mammary adipocytes bioactivate 25-hydroxyvitamin D and signal via vitamin D receptor, modulating mammary epithelial cell growth. J Cell Biochem 112(11):3393–3405

    PubMed  Article  CAS  Google Scholar 

  16. Beer AE, Billingham RE (1978) Adipose tissue, a neglected factor in aetiology of breast cancer? Lancet 2(8084):296

    PubMed  Article  CAS  Google Scholar 

  17. Levental KR, Yu H, Kass L et al (2009) Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139(5):891–906

    PubMed  Article  CAS  Google Scholar 

  18. Paszek MJ, Zahir N, Johnson KR et al (2005) Tensional homeostasis and the malignant phenotype. Cancer Cell 8(3):241–254

    PubMed  Article  CAS  Google Scholar 

  19. Provenzano PP, Inman DR, Eliceiri KW, Keely PJ (2009) Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage. Oncogene 28(49):4326–4343

    PubMed  Article  CAS  Google Scholar 

  20. Ronnov-Jessen L, Bissell MJ (2009) Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends Mol Med 15(1):5–13

    PubMed  Article  Google Scholar 

  21. Brower V (2010) Homing in on mechanisms linking breast density to breast cancer risk. J Natl Cancer Inst 102(12):843–845

    PubMed  Article  Google Scholar 

  22. Butcher DT, Alliston T, Weaver VM (2009) A tense situation: forcing tumour progression. Nat Rev Cancer 9(2):108–122

    PubMed  Article  CAS  Google Scholar 

Download references

Acknowledgments

We thank Drs. Pagona Lagiou and Dimitrios Trichopoulos for valuable suggestions on the manuscript.

Conflict of interest

None.

Author information

Affiliations

  1. Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA

    Andreas Pettersson & Rulla M. Tamimi

  2. Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA

    Rulla M. Tamimi

Authors
  1. Andreas Pettersson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rulla M. Tamimi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rulla M. Tamimi.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Pettersson, A., Tamimi, R.M. Breast fat and breast cancer. Breast Cancer Res Treat 135, 321–323 (2012). https://doi.org/10.1007/s10549-012-2186-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10549-012-2186-2

Keywords

  • Breast Cancer
  • Breast Cancer Risk
  • Mammographic Density
  • Dense Area
  • Postmenopausal Breast Cancer