Breast Cancer Research and Treatment

, Volume 133, Issue 1, pp 375–385

Social networks, social support and burden in relationships, and mortality after breast cancer diagnosis

  • Candyce H. Kroenke
  • Yvonne Michael
  • Hilary Tindle
  • Elizabeth Gage
  • Rowan Chlebowski
  • Lorena Garcia
  • Catherine Messina
  • JoAnn E. Manson
  • Bette J. Caan
Epidemiology

DOI: 10.1007/s10549-012-1962-3

Cite this article as:
Kroenke, C.H., Michael, Y., Tindle, H. et al. Breast Cancer Res Treat (2012) 133: 375. doi:10.1007/s10549-012-1962-3

Abstract

Though larger social networks are associated with reduced breast cancer mortality, there is a need to clarify how both social support and social burden influence this association. We included 4,530 women from the Women’s Health Initiative who were diagnosed with breast cancer between 1993 and 2009, and provided data on social networks (spouse or intimate partner, religious ties, club ties, and number of first-degree relatives) before diagnosis. Of those, 354 died during follow-up, with 190 from breast cancer. We used Cox proportional hazards regression to evaluate associations of social network members with risk of post-diagnosis mortality, further evaluating associations by social support and social burden (caregiving, social strain). In multivariate-adjusted analyses, among women with high but not low social support, being married was related to lower all-cause mortality. By contrast, among women with high but not low social burden, those with a higher number of first-degree relatives, including siblings, parents, and children, had higher all-cause and breast cancer mortality (among caregivers: 0–3 relatives (ref), 4–5 relatives, HR = 1.47 (95% CI: 0.62–3.52), 6–9 relatives, HR = 2.08 (95% CI: 0.89–4.86), 10+ relatives, HR = 3.55 (95% CI: 1.35–9.33), P-continuous = 0.02, P-interaction = 0.008). The association by social strain was similar though it was not modified by level of social support. Other social network members were unrelated to mortality. Social relationships may have both adverse and beneficial influences on breast cancer survival. Clarifying these depends on understanding the context of women’s relationships.

Keywords

Social networks Social support Social burden Social relationships Caregiving Stress Breast cancer Mortality Women 

Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  • Candyce H. Kroenke
    • 1
  • Yvonne Michael
    • 2
  • Hilary Tindle
    • 3
  • Elizabeth Gage
    • 4
  • Rowan Chlebowski
    • 5
  • Lorena Garcia
    • 6
  • Catherine Messina
    • 7
  • JoAnn E. Manson
    • 8
  • Bette J. Caan
    • 9
  1. 1.Kaiser Permanente, Division of ResearchOaklandUSA
  2. 2.Department of Epidemiology and BiostatisticsDrexel University School of Public HealthPhiladelphiaUSA
  3. 3.Division of General Internal MedicineUniversity of PittsburghPittsburghUSA
  4. 4.School of Public HealthUniversity at Buffalo, State University of New YorkBuffaloUSA
  5. 5.David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  6. 6.School of MedicineUniversity of CaliforniaDavisUSA
  7. 7.Department of Preventive MedicineStony Brook UniversityStony BrookUSA
  8. 8.Division of Preventive MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  9. 9.Kaiser Permanente, Division of ResearchOaklandUSA

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