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Genetic variants at chromosome 9p21, 10p15 and 10q22 and breast cancer susceptibility in a Chinese population

  • Epidemiology
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Abstract

A recent genome-wide association study (GWAS) has identified a new subset of breast cancer susceptibility loci on chromosomes 9, 10, and 11 in populations of European descent. However, because of the genetic heterogeneity, the role of these loci in non-European descent populations is still unclear. To evaluate the relationships between genetic variants in these regions identified by GWAS and breast cancer risk in Chinese women, we genotyped four common SNPs at 9p21(rs1011970 and rs10757278), 10p15 (rs2380205), and 10q22 (rs1250009) in a two-stage case–control study with a total of 1792 breast cancer cases and 1,867 controls. We found that rs1250009 at 10q22 was consistently associated with risk of breast cancer in stage 1 and stage 2, with a per-allele OR of 1.13 (95% CI 1.02–1.25) after two stages combined (P = 0.023). However, no significant associations were observed between the other three SNPs and breast cancer risk. Our results suggest that the genetic variants at 10q22 may play an important role in breast cancer development in Chinese women, and rs1250009 may be a candidate marker for breast cancer susceptibility.

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Acknowledgments

Funding support for this project was provided by the National Natural Science Foundation of China (grant number 81071715; 81102179), Key Grant of Natural Science Foundation of Jiangsu Higher Education Institutions (09KJA330001), The Program for Changjiang Scholars and Innovative Research Team in University (IRT0631).We thank the study participants and research staff for their contributions and commitment to this study.

Conflicts of interest

No potential conflicts of interest were disclosed.

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Authors and Affiliations

  1. MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, 210029, China

    Jiaping Chen, Yue Jiang, Zhenzhen Qin, Juncheng Dai, Guangfu Jin, Hongxia Ma, Xinru Wang, Zhibin Hu & Hongbing Shen

  2. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, 210029, China

    Yue Jiang, Guangfu Jin, Hongxia Ma, Xinru Wang, Zhibin Hu & Hongbing Shen

  3. Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China

    Jiaping Chen, Yue Jiang, Guangfu Jin, Zhibin Hu & Hongbing Shen

  4. Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    Xiaoan Liu & Shui Wang

Authors
  1. Jiaping Chen
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  2. Yue Jiang
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  3. Xiaoan Liu
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  4. Zhenzhen Qin
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  8. Shui Wang
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  9. Xinru Wang
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  10. Zhibin Hu
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  11. Hongbing Shen
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Correspondence to Hongbing Shen.

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Chen, J., Jiang, Y., Liu, X. et al. Genetic variants at chromosome 9p21, 10p15 and 10q22 and breast cancer susceptibility in a Chinese population. Breast Cancer Res Treat 132, 741–746 (2012). https://doi.org/10.1007/s10549-011-1927-y

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  • DOI: https://doi.org/10.1007/s10549-011-1927-y

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