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Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry

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Abstract

As one of the most common cancers worldwide, breast cancer places an extraordinary burden on the populations of African ancestry. Common SNPs in the TERT-CLPTM1L locus have been reported to be associated with several types of cancer, including breast cancer. We sought to investigate whether the previously reported common single nucleotide polymorphisms (SNPs) in the TERT-CLPTM1L locus could also contribute to the breast cancer risk in women of African ancestry. We genotyped eleven SNPs in 2,892 women of African descent but were unable to detect any significant association between TERT-CLPTM1L SNPs and their predispositions for breast cancer risk. Given the differences in linkage disequilibrium patterns across populations, our findings suggest that larger independent studies from diverse populations are expected to evaluate the importance of the TERT-CLPTM1L locus in breast cancer.

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Acknowledgment

This study was supported by grants from the National Cancer Institute at the United States National Institutes of Health (R01 CA141712, R01 CA142996-01, P50 CA125183), Entertainment Industry Foundation, Falk Medical Research Trust, Susan G Komen for the Cure, and Breast Cancer Research Foundation. The Northern California site of the Breast Cancer Family Registry (BCFR) was supported by the United States National Cancer Institute, National Institutes of Health (NIH) under RFA-CA-06-503 and through cooperative agreements with members of the BCFR and Principal Investigators, including the Northern California Cancer Center (U01 CA69417). Samples from the Northern California site were processed and distributed by the Coriell Institute for Medical Research. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the BCFR, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the BCFR.

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Medicine, The University of Chicago, 900 E 57th Street, KCBD Building 8113D, Chicago, IL, 60637, USA

    Yonglan Zheng

  2. Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Temidayo O. Ogundiran

  3. Department of Epidemiology & Preventive Medicine, University of Maryland, Baltimore, MD, USA

    Clement Adebamowo

  4. Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Katherine L. Nathanson & Susan M. Domchek

  5. Department of Statistics & Epidemiology, University of Pennsylvania, Philadelphia, PA, USA

    Timothy R. Rebbeck

  6. Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA

    Michael S. Simon

  7. Cancer Prevention Institute of California, Fremont, CA, USA

    Esther M. John

  8. Department of Health Research & Policy, Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA, USA

    Esther M. John

  9. Chronic Disease Research Centre and Tropical Medicine Research Institute, University of the West Indies, Bridgetown, Barbados

    Anselm Hennis

  10. Department of Preventive Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA

    Barbara Nemesure, Suh-Yuh Wu & Maria Cristina Leske

  11. Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD, USA

    Stefan Ambs

  12. Department of Medicine, The University of Chicago, Chicago, IL, USA

    Qun Niu, Jing Zhang, Nancy J. Cox & Olufunmilayo I. Olopade

  13. Department of Health Studies, The University of Chicago, 5841 South Maryland Ave., MC 2007, Chicago, IL, 60637, USA

    Dezheng Huo

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  1. Yonglan Zheng
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  2. Temidayo O. Ogundiran
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  3. Clement Adebamowo
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  9. Anselm Hennis
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  11. Suh-Yuh Wu
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  14. Qun Niu
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  15. Jing Zhang
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  16. Nancy J. Cox
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  17. Olufunmilayo I. Olopade
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  18. Dezheng Huo
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Correspondence to Yonglan Zheng or Dezheng Huo.

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Zheng, Y., Ogundiran, T.O., Adebamowo, C. et al. Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry. Breast Cancer Res Treat 132, 341–345 (2012). https://doi.org/10.1007/s10549-011-1890-7

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  • DOI: https://doi.org/10.1007/s10549-011-1890-7

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