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Prognostic role of CA15.3 in 7942 patients with operable breast cancer

  • Epidemiology
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Abstract

To assess the prognostic value of presurgical CA15.3 in a large cohort of patients with early breast cancer. A total of 7.942 consecutive patients with breast cancer operated at the European Institute of Oncology between 1998 and 2005 and with presurgical values of CA 15.3 available were included. We explored patterns of recurrence by baseline CA 15.3 values. Mean CA15.3 was 17.0 U/ml. CA15.3 was associated with age, tumor size, nodal involvement, Ki-67 labeling index, grade, HER2 expression, molecular subtype, and perivascular invasion. CA15.3 was independently associated with distant metastases [HR > 20 U/ml vs. ≤ 20 U/ml: 1.34 (95% CI 1.15–1.56)] and death [HR > 20 U/ml vs. ≤ 20 U/ml: 1.30 (95% CI 1.11–1.53)]. When considering CA15.3 as continuous variable, we observed a constant risk of metastasis and death from the lowest values to about 15–20 U/ml, and then a significantly increasing risk with increasing values of CA15.3. Finally, CA15.3 provided significant additional information to the common prognostic factors to predict the occurrence of metastases (C-index P value 0.04). In patients with operable breast cancer, presurgical CA15.3 value is an independent prognostic factor for metastases and deaths. CA15.3 provides additional information to the common prognostic factors and should be considered in the adjuvant therapeutic algorithm.

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Authors and Affiliations

  1. Division of Laboratory Medicine, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy

    M. T. Sandri, M. Salvatici, R. Passerini, L. Zorzino, C. Mauro, M. C. Cassatella & F. Bottari

  2. Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy

    E. Botteri, N. Rotmensz & V. Bagnardi

  3. Institute of Medical Statistics and Biometrics ‘G. A. Maccacaro’, University of Milan, Milan, Italy

    E. Botteri

  4. Division of Senology, European Institute of Oncology, Milan, Italy

    A. Luini

  5. Department of Statistics, University of Milan-Bicocca, Milan, Italy

    V. Bagnardi

  6. Unit of Diagnostic Cytology, Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy

    C. Casadio

  7. Research Unit in Medical Senology, Department of Medicine, European Institute of Oncology, Milan, Italy

    M. Colleoni

Authors
  1. M. T. Sandri
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  2. M. Salvatici
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  3. E. Botteri
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  4. R. Passerini
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  5. L. Zorzino
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  7. A. Luini
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  8. C. Mauro
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  9. V. Bagnardi
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  10. M. C. Cassatella
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  11. F. Bottari
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  12. C. Casadio
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  13. M. Colleoni
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Correspondence to M. T. Sandri.

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Sandri, M.T., Salvatici, M., Botteri, E. et al. Prognostic role of CA15.3 in 7942 patients with operable breast cancer. Breast Cancer Res Treat 132, 317–326 (2012). https://doi.org/10.1007/s10549-011-1863-x

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  • DOI: https://doi.org/10.1007/s10549-011-1863-x

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