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Carotenoids and breast cancer risk: a meta-analysis and meta-regression

Breast Cancer Research and Treatment volume 131, pages 239–253 (2012)Cite this article

Abstract

The purpose of this article is to comprehensively summarize the associations between carotenoids and breast cancer and quantitatively estimate their dose–response relationships. We searched PubMed, Embase, and Cochrane databases (from January 1982 to 1 May 2011) and the references of the relevant articles in English with sufficient information to estimate relative risk or odds ratio and the 95% confidence intervals, and comparable categories of carotenoids. Two reviewers independently extracted data using a standardized form; with any discrepancy adjudicated by the third reviewer. 33 studies met the inclusion criteria. Comparing the highest with the lowest intake: dietary α-carotene intake significantly reduced the breast cancer risk by 9.0% (pooled RR = 0.91; 95% CI: 0.85–0.98; P = 0.01), dietary β-carotene intake reduced the risk by 6.0% (pooled RR = 0.94; 95% CI: 0.88–1.00; P = 0.05); total β-carotene intake reduced the risk by 5.0% (pooled RR = 0.95; 95% CI: 0.90–1.01; P = 0.08) when data from cohort studies were pooled. Significant dose–response relationships were observed in both the higher intake of dietary and total β-carotene with reduced breast cancer risk when data from cohort studies (P trend < 0.01, P trend = 0.03) and case–control studies (P trend < 0.01, P trend < 0.01) were pooled, respectively. Dietary α-carotene intake could reduce the breast cancer risk. The relationships between dietary and total β-carotene intake and breast cancer need to be confirmed. No significant association between dietary intake of β-cryptoxanthin, lutein/+zeaxanthin, and lycopene and breast cancer was observed.

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Acknowledgment

The authors thank J. Love for reviewing the paper.

Conflict of interest

All authors read and approved the final manuscript. None of the authors had any conflicts of interest.

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Authors and Affiliations

  1. Department of Epidemiology, Public Health College, Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, Heilongjiang, People’s Republic of China

    Fulan Hu, Baina Wang Yi, Wencui Zhang, Jing Liang, Chunqing Lin, Dandan Li, Fan Wang & Yashuang Zhao

  2. Department of Breast Surgery, Cancer Hospital of Harbin Medical University, 150 Haping Street, Nangang District, Harbin, Heilongjiang, People’s Republic of China

    Da Pang

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  1. Fulan Hu
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Appendix

Appendix

See Figs. 6 and 7.

Fig. 6
figure 6

The forest plots for the associations between dietary β-cryptoxanthin (a), dietary lutein/+zeaxanthin (b), and dietary lycopene (c) and the breast cancer pooling on cohort studies

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Fig. 7
figure 7

The forest plots for the associations between dietary β-cryptoxanthin (a), dietary lutein/+zeaxanthin (b), and dietary lycopene (c) and the breast cancer pooling on case–control studies

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Hu, F., Wang Yi, B., Zhang, W. et al. Carotenoids and breast cancer risk: a meta-analysis and meta-regression. Breast Cancer Res Treat 131, 239–253 (2012). https://doi.org/10.1007/s10549-011-1723-8

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Keywords

  • Carotenoids
  • Breast cancer
  • Meta-analysis
  • Meta-regression