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Lifecourse predictors of mammographic density: the Newcastle Thousand Families cohort Study

Breast Cancer Research and Treatment volume 131, pages 187–195 (2012)Cite this article

Abstract

Dense mammographic patterns are a strong predictor of breast cancer risk. Factors at differing stages of life have been linked to breast cancer risk, although rarely studied simultaneously. We aimed to investigate whether birth weight and factors later in life were associated with mammographic density in the Newcastle Thousand Families Study. The Study originally consisted of all 1142 babies born in May and June 1947 to mothers resident in Newcastle upon Tyne in Northern England. Detailed information was collected prospectively during childhood, including birth weight and socio-economic circumstances. At age 49–51 years, 574 study members completed a ‘Health and Lifestyle’ questionnaire. Of the 307 surviving women who returned these questionnaires, 199 returned a further questionnaire asking for details of routine mammographic screening, their reproductive and contraceptive history. Mammographic patterns were coded into Wolfe categories. This was analysed, by ordinal logistic regression, in relation to a range of variables at different stages of life. Increased standardised birth weight (odds ratio, OR 1.32 (95% CI 1.02–1.71) P = 0.03) was a significant independent predictor of higher density. Increasing body mass index (BMI) was predictive of lower density (OR 0.86 per Kg/m2 (95% CI 0.81–0.92) P < 0.001), as was having reached menopause (OR, compared to pre- and peri-menopausal, 0.41 (95% CI 0.23–0.73) P = 0.002). Interactions were seen between menopausal status and both BMI and age at menarche (P = 0.06) on density, although for neither did the direction of association change. After adjustment for factors acting throughout life, we identified a significant association between standardised birth weight and density in adulthood, consistent with previous research suggesting that heavier babies have an increased risk of breast cancer in later life. We also confirmed associations between both BMI and menopausal status.

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Abbreviations

aOR:

Adjusted odds ratio

BMI:

Body Mass Index

OR:

Odds ratio

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Acknowledgments

We thank the participating study members for this study and the study, teams and funders of the past and present. The Newcastle Healthcare Charity funded this study.

Conflict of interest

The authors declare that they have no competing interests and funding.

Author information

Affiliations

  1. Institute of Health and Society, Newcastle University, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK

    Mark S. Pearce, Peter W. G. Tennant & Kay D. Mann

  2. Department of Anthropology, University of Durham, Durham, UK

    Tessa M. Pollard

  3. Breast Screening Centre, Royal Victoria Infirmary, Newcastle upon Tyne, UK

    Lesley McLean & Brenda Kaye

  4. Departments of Medicine and Paediatrics, Dalhousie University, Halifax, Canada

    Louise Parker

Authors
  1. Mark S. Pearce
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  2. Peter W. G. Tennant
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  3. Kay D. Mann
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  4. Tessa M. Pollard
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  5. Lesley McLean
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  6. Brenda Kaye
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  7. Louise Parker
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Correspondence to Mark S. Pearce.

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Pearce, M.S., Tennant, P.W.G., Mann, K.D. et al. Lifecourse predictors of mammographic density: the Newcastle Thousand Families cohort Study. Breast Cancer Res Treat 131, 187–195 (2012). https://doi.org/10.1007/s10549-011-1708-7

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  • DOI: https://doi.org/10.1007/s10549-011-1708-7

Keywords

  • Breast cancer
  • Mammographic density
  • Birth weight
  • Lifecourse
  • Cohort