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Current evidences on XPC polymorphisms and breast cancer susceptibility: a meta-analysis

  • Epidemiology
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

Published data on the association between three polymorphisms (Lys939Gln, Ala499Val, and PAT±) of Xeroderma Pigmentosum group C (XPC) and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between them. A total of 11 studies including 5,090 cases and 5,214 controls were involved in this meta-analysis. For XPC Lys939Gln polymorphism, no obvious associations were found for all genetic models when all studies were pooled into the meta-analysis (Lys/Gln vs. Lys/Lys: OR = 1.00, 95% CI 0.92–1.10; Gln/Gln vs. Lys/Lys: OR = 0.96, 95% CI 0.84–1.09; dominant model: OR = 0.99, 95% CI 0.91–1.08; and recessive model: OR = 0.97, 95% CI 0.86–1.09). In the subgroup analysis by ethnicity or study design, still no obvious associations were found. For XPC Ala499Val polymorphism, also no obvious associations were found for all genetic models when all studies were pooled into the meta-analysis (Val/Ala vs. Ala/Ala: OR = 0.91, 95% CI 0.79–1.05; Val/Val vs. Ala/Ala: OR = 1.07, 95% CI 0.80–1.44; dominant model: OR = 0.93, 95% CI 0.81–1.06; and recessive model: OR = 1.11, 95% CI 0.84–1.48). For XPC PAT± polymorphism, obvious associations were found for recessive model when all studies were pooled into the meta-analysis (OR = 1.41, 95% CI 1.05–1.89). In conclusion, this meta-analysis suggests that the XPC PAT± polymorphism allele may be a low-penetrant risk factor for developing breast cancer.

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Authors and Affiliations

  1. Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China

    Wei Zheng, Xiu-Feng Cong, Wei-Hao Cai & Hua-Wei Zou

  2. Department of Medical Oncology, The Union Hospital, Fu Jian Medical University, Fuzhou, China

    Sheng Yang

  3. Department of Epidemiology, School of Public Health and Primary Care, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

    Chen Mao

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  1. Wei Zheng
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  2. Xiu-Feng Cong
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  3. Wei-Hao Cai
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  4. Sheng Yang
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  5. Chen Mao
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  6. Hua-Wei Zou
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Correspondence to Hua-Wei Zou.

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Zheng, W., Cong, XF., Cai, WH. et al. Current evidences on XPC polymorphisms and breast cancer susceptibility: a meta-analysis. Breast Cancer Res Treat 128, 811–815 (2011). https://doi.org/10.1007/s10549-011-1369-6

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  • DOI: https://doi.org/10.1007/s10549-011-1369-6

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