Soy consumption and breast cancer risk: four recent meta-analyses
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To the Editor,
We read with great interest the recent meta-analysis conducted by Dong et al. , which has examined the association between soy isoflavones consumption and risk of breast cancer incidence or recurrence, using all available prospective studies to date. They found that soy isoflavones consumption was inversely associated with risk of breast cancer incidence (RR = 0.89, 95% CI: 0.79–0.99). However, the protective effect of soy was only observed among studies conducted in Asian populations (RR = 0.76, 95% CI: 0.65–0.86) but not in Western populations (RR = 0.97, 95% CI: 0.87–1.06). Soy isoflavones intake was also inversely associated with risk of breast cancer recurrence (RR = 0.84, 95% CI: 0.70–0.99). Stratified analyses suggested that menopausal status may be an important effect modifier in these associations. However, I have several concerns.
KeywordsBreast Cancer Breast Cancer Risk Isoflavones Western Population Breast Cancer Incidence
References for Rebuttal Letter