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Breast Cancer Research and Treatment

, Volume 127, Issue 2, pp 573–576 | Cite as

Soy consumption and breast cancer risk: four recent meta-analyses

  • Chun Zhang
  • Jian-Ping Li
  • Ping ZhouEmail author
Letter to the Editor

To the Editor,

We read with great interest the recent meta-analysis conducted by Dong et al. [1], which has examined the association between soy isoflavones consumption and risk of breast cancer incidence or recurrence, using all available prospective studies to date. They found that soy isoflavones consumption was inversely associated with risk of breast cancer incidence (RR = 0.89, 95% CI: 0.79–0.99). However, the protective effect of soy was only observed among studies conducted in Asian populations (RR = 0.76, 95% CI: 0.65–0.86) but not in Western populations (RR = 0.97, 95% CI: 0.87–1.06). Soy isoflavones intake was also inversely associated with risk of breast cancer recurrence (RR = 0.84, 95% CI: 0.70–0.99). Stratified analyses suggested that menopausal status may be an important effect modifier in these associations. However, I have several concerns.

First, this meta-analysis was similar to the researches by Enderlin et al. [2], Trock et al. [3], and Qin et al. [4]. However,...

Keywords

Breast Cancer Breast Cancer Risk Isoflavones Western Population Breast Cancer Incidence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Dong JY, Qin LQ (2011) Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat 125(2):315–323PubMedCrossRefGoogle Scholar
  2. 2.
    Enderlin CA, Coleman EA, Stewart CB, Hakkak R (2009) Dietary soy intake and breast cancer risk. Oncol Nurs Forum 36(5):531–539PubMedCrossRefGoogle Scholar
  3. 3.
    Trock BJ, Hilakivi-Clarke L, Clarke R (2006) Meta-analysis of soy intake and breast cancer risk. J Natl Cancer Inst 98(7):459–471PubMedCrossRefGoogle Scholar
  4. 4.
    Qin LQ, Xu JY, Wang PY, Hoshi K (2006) Soyfood intake in the prevention of breast cancer risk in women: a meta-analysis of observational epidemiological studies. J Nutr Sci Vitaminol (Tokyo) 52(6):428–436CrossRefGoogle Scholar

References for Rebuttal Letter

  1. 1.
    Dong JY, Qin LQ (2011) Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat 125(2):315–323PubMedCrossRefGoogle Scholar
  2. 2.
    Wu AH, Yu MC, Tseng CC, Pike MC (2008) Epidemiology of soy exposures and breast cancer risk. Br J Cancer 98(1):9–14PubMedCrossRefGoogle Scholar
  3. 3.
    Trock BJ, Hilakivi-Clarke L, Clarke R (2006) Meta-analysis of soy intake and breast cancer risk. J Natl Cancer Inst 98(7):459–471PubMedCrossRefGoogle Scholar
  4. 4.
    Qin LQ, Xu JY, Wang PY, Hoshi K (2006) Soyfood intake in the prevention of breast cancer risk in women: a meta-analysis of observational epidemiological studies. J Nutr Sci Vitaminol (Tokyo) 52(6):428–436CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  1. 1.Department of General SurgeryThe Third Affiliated Hospital to Nantong UniversityWuxiChina
  2. 2.Department of Intensive Care UniteThe Third Affiliated Hospital to Nantong UniversityWuxiChina

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