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The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis

Breast Cancer Research and Treatment volume 125, pages 571–574 (2011)Cite this article

Abstract

Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) which located in the pre-miRNA may affect the processing and then influence the expression of mature miRNA. Previous studies yielded conflicting results as to the association of two common polymorphisms in pre-miRNAs (i.e. hsa-miR-146 rs2910164 and hsa-miR-196a2 rs11614913) with breast cancer. To derive a more precise effect on the association between these polymorphisms and breast cancer risk, we conducted a meta-analysis. Through retrieving PubMed for the period up to May 2010, a total of four studies were identified with 3,007 cases and 3,718 controls for has-miR-146a rs2910164 polymorphism and with 3,287 cases and 4,298 controls for hsa-miR-196a2 rs11614913 polymorphism. We found that individuals carrying CC genotype of has-miR-196a2 rs11614913 polymorphism was associated with an increased breast cancer risk in homozygote comparison (OR = 1.30; 95% CI, 1.01-1.68), and dominant model (OR = 1.11; 95% CI, 1.01-1.23). However, no significant association between has-miR-146a rs2910164 polymorphism and breast cancer risk was observed in all comparison models tested. These findings suggest that has-miR-196a2 rs11614913 polymorphism may play crucial roles in breast cancer development.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 30901720, 30801317).

Conflict of interest statement

None of the authors has any potential financial conflict of interest related to this manuscript.

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Affiliations

  1. Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R.China

    Lin-Bo Gao & Lin Zhang

  2. Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R.China

    Peng Bai, Xin-Min Pan, Li-Juan Li, Wei-Bo Liang & Lu-Shun Zhang

  3. Department of Forensic Pathology, Henan University of Science and Technology, Luoyang, Henan, 471003, P.R.China

    Xin-Min Pan

  4. Department of Normal Pharmacology, Zhejiang Academy of Medical Sciences (ZAMS), Hangzhou, Zhejiang, 310013, P.R.China

    Jing Jia

  5. Department of Pathology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, 650000, P.R.China

    Ming Tang

  6. Department of General Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, P.R.China

    Yong-Gang Wei

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  1. Lin-Bo Gao
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  2. Peng Bai
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  3. Xin-Min Pan
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  7. Ming Tang
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  8. Lu-Shun Zhang
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  9. Yong-Gang Wei
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  10. Lin Zhang
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Correspondence to Lin Zhang.

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Lin-Bo Gao, Peng Bai, These two authors are contributed equally to this work.

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Gao, LB., Bai, P., Pan, XM. et al. The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 125, 571–574 (2011). https://doi.org/10.1007/s10549-010-0993-x

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  • DOI: https://doi.org/10.1007/s10549-010-0993-x

Keywords

  • Hsa-miR-146 rs2910164
  • Has-miR-196a2 rs11614913
  • Single nucleotide polymorphism
  • Breast cancer
  • Meta-analysis