References
Pusztai L, Leyland-Jones B (2008) Promises and caveats of in-silico biomarker discovery. Br J Cancer 99:385–386
Gyorffy B, Lanczky A, Eklund AC et al (2010) An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1809 patients. Breast Cancer Res Treat. doi:10.1007/s10549-009-0674-9
Greenbaum D, Colangelo C, Williams K et al. (2003) Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol 4: 117–117.8
Lu P, Vogel C, Wang R et al (2007) Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation. Nat Biotechnol 25:117–124
Schmidt M, Hasenclever D, Schaeffer M et al (2008) Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer. Clin Cancer Res 14:5849–5855
Andre F, Hatzis C, Anderson K et al (2007) Microtubule-associated protein-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor-positive breast cancer. Clin Cancer Res 13:2061–2067
Iwamoto T, Bianchini G, Coutant C et al (2009) Different biological processes are associated with prognosis and chemotherapy sensitivity in the different molecular subtypes of breast cancer. Cancer Res 69(Suppl):864s (Abs 6124)
Schmidt M, Scheulie ME, Dittrich C et al (2010) An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer. Ann Oncol 21:275–282
Simon RM, Paik S, Hayes DF (2009) Use of archived specimens in evaluation of prognostic and predictive biomarkers. J Natl Cancer Inst 101:1446–1452
Sotiriou C, Pusztai L (2009) Gene-expression signatures in breast cancer. N Engl J Med 360:790–800
Wirapati P, Sotiriou C, Kunkel S, Farmer et al (2008) Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res 10:R65
Yu JX, Sieuwerts AM, Zhang Y et al (2007) Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer. BMC Genomics 7:182. doi:10.1186/1471-2407-7-182
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This is an invited commentary to article doi:10.1007/s10549-010-0856-5.
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Pusztai, L., Iwamoto, T. Breast cancer prognostic markers in the post-genomic era. Breast Cancer Res Treat 125, 647–650 (2011). https://doi.org/10.1007/s10549-010-0932-x
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DOI: https://doi.org/10.1007/s10549-010-0932-x