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MTRR A66G polymorphism and breast cancer risk: a meta-analysis

  • Epidemiology
  • Published:
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Abstract

Methionine synthase reductase (MTRR) is one of the important enzymes involved in the folate metabolic pathway and its functional genetic polymorphisms may be associated with breast cancer risk. However, this relationship remains inconclusive. For better understanding the effect of MTRR A66G polymorphism on breast cancer risk, a meta-analysis was performed. By searching PubMed and EMBASE, a total of six case–control studies, containing 6,084 cases and 6,756 controls, were included. The strength of association between MTRR A66G polymorphism and breast cancer risk was assessed by odds ratio (OR) with the corresponding 95% confidence interval (95% CI). The results strongly suggested that there was no significant association between MTRR A66G polymorphism and breast cancer susceptibility in overall comparisons in all genetic models (additive model: OR 1.00, 95% CI 0.89–1.11, P = 0.943; dominant model: OR 1.00, 95% CI 0.91–1.10, P = 0.989; recessive model: OR 1.00, 95% CI 0.91–1.09, P = 0.926). Similarly, in subgroup analyses for ethnicity (Caucasian, Asian and mixed population) and folate intake status (high and low folate intake), the results were negative. Sensitivity analysis demonstrated that omitting any study did not perturb the results. In conclusion, this meta-analysis strongly suggests that MTRR A66G polymorphism is not associated with breast cancer risk, especially in Caucasians and Asians.

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Authors and Affiliations

  1. Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, People’s Republic of China

    Jia Hu, Ning Wang & Ya-Jie Wang

  2. Department of Respiration, Changhai Hospital, Second Military Medical University, Shanghai, 200433, People’s Republic of China

    Guo-Wu Zhou

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  1. Jia Hu
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  2. Guo-Wu Zhou
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  3. Ning Wang
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  4. Ya-Jie Wang
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Correspondence to Ya-Jie Wang.

Additional information

J. Hu and G.-W. Zhou equally contributed to this study.

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Hu, J., Zhou, GW., Wang, N. et al. MTRR A66G polymorphism and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 124, 779–784 (2010). https://doi.org/10.1007/s10549-010-0892-1

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  • DOI: https://doi.org/10.1007/s10549-010-0892-1

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