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The androgen receptor in breast cancer: learning from the past

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References

  1. Hammond EH, Hayes DF, Dowsett M et al (2010) American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for immunohistochemical testing of estrogen/progesterone receptors in breast cancer. J Clin Oncol (in press)

  2. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365:1687–1717

    Article  Google Scholar 

  3. Clarke M, Coates AS, Darby SC et al (2008) Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials. Lancet 371:29–40

    Article  CAS  PubMed  Google Scholar 

  4. Osborne CK, Yochmowitz MG, Knight WA III et al (1980) The value of estrogen and progesterone receptors in the treatment of breast cancer. Cancer 46:2884–2888

    Article  CAS  PubMed  Google Scholar 

  5. Castellano I, Allia E, Accortanzo V et al (2010) Androgen receptor expression is a significant prognostic factor in estrogen receptor positive breast cancers. Breast Cancer Res Treat. doi:10.1007/s10549-010-0761-y

  6. Agoff SN, Swanson PE, Linden H et al (2003) Androgen receptor expression in estrogen receptor-negative breast cancer. Immunohistochemical, clinical, and prognostic associations. Am J Clin Pathol 120:725–731

    Article  CAS  PubMed  Google Scholar 

  7. Yeh S, Hu YC, Wang PH et al (2003) Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J Exp Med 198:1899–1908

    Article  CAS  PubMed  Google Scholar 

  8. Schippinger W, Regitnig P, Dandachi N et al (2006) Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer. Virchows Arch 449:24–30

    Article  CAS  PubMed  Google Scholar 

  9. Moinfar F, Okcu M, Tsybrovskyy O et al (2003) Androgen receptors frequently are expressed in breast carcinomas: potential relevance to new therapeutic strategies. Cancer 98:703–711

    Article  CAS  PubMed  Google Scholar 

  10. Kuenen-Boumeester V, Van der Kwast TH, Claassen CC et al (1996) The clinical significance of androgen receptors in breast cancer and their relation to histological and cell biological parameters. Eur J Cancer 32A:1560–1565

    Article  CAS  PubMed  Google Scholar 

  11. Ogawa Y, Hai E, Matsumoto K et al (2008) Androgen receptor expression in breast cancer: relationship with clinicopathological factors and biomarkers. Int J Clin Oncol 13:431–435

    Article  CAS  PubMed  Google Scholar 

  12. Clarke BL, Khosla S (2009) New selective estrogen and androgen receptor modulators. Curr Opin Rheumatol 21:374–379

    Article  CAS  PubMed  Google Scholar 

  13. Cheang MC, Chia SK, Voduc D et al (2009) Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst 101:736–750

    Article  CAS  PubMed  Google Scholar 

  14. McShane LM, Altman DG, Sauerbrei W et al (2006) Reporting recommendations for tumor marker prognostic studies (REMARK). Breast Cancer Res Treat 100:229–235

    Article  PubMed  Google Scholar 

  15. Peters AA, Buchanan G, Ricciardelli C et al (2009) Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. Cancer Res 69:6131–6140

    Article  CAS  PubMed  Google Scholar 

  16. Gonzalez-Angulo AM, Stemke-Hale K, Palla SL et al (2009) Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer. Clin Cancer Res 15:2472–2478

    Article  CAS  PubMed  Google Scholar 

  17. Sanga S, Broom BM, Cristini V et al (2009) Gene expression meta-analysis supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB family. BMC Med Genomics 2:59

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. The Johns Hopkins Kimmel Cancer Center, 1650 Orleans Street, CRB1-189, Baltimore, MD, 21231-1000, USA

    Michaela J. Higgins & Antonio C. Wolff

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  1. Michaela J. Higgins
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  2. Antonio C. Wolff
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Correspondence to Antonio C. Wolff.

Additional information

This is an invited commentary to article doi:10.1007/s10549-010-0761-y.

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Higgins, M.J., Wolff, A.C. The androgen receptor in breast cancer: learning from the past. Breast Cancer Res Treat 124, 619–621 (2010). https://doi.org/10.1007/s10549-010-0864-5

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  • DOI: https://doi.org/10.1007/s10549-010-0864-5

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