Abstract
Trinucleotide repeat-containing 9 (TNRC9), a high mobility group chromatin-associated protein, has been implicated in breast cancer metastasis to the bone. Recently, several single nucleotide polymorphisms (SNPs) of TNRC9 were identified as novel breast cancer susceptibility loci by whole genome association studies, especially in estrogen receptor (ER) positive tumors. In the present case–control study of 1,049 breast cancer patients and 1,073 cancer-free controls in a Chinese population, we genotyped three polymorphisms (rs3803662C/T, rs12443621A/G, and rs8051542C/T) of the TNRC9 gene using the SNPstream 12-plex platform to test the hypothesis that these SNPs are associated with breast cancer risk in this population. None of the three polymorphisms was significantly associated with breast cancer risk in the whole data set (P = 0.151, 0.644, and 0.737 for rs3803662, rs12443621. and rs8051542, respectively). However, rs12443621 AG/GG genotypes were significantly associated with increased risk of ER positive breast cancer (OR = 1.38, 95% CI = 1.01–1.88), compared with homozygote AA. In addition, a borderline significantly increased risk was also observed for the variant genotypes (CT/TT) of rs8051542 C/T compared with the wild-type genotype (CC) (adjusted OR = 1.26, 95% CI = 0.99–1.60). Interestingly, a significant interaction was detected between rs12443621A/G and ER status on breast cancer risk in a case-only analysis (P for interaction = 0.004). These findings suggest that genetic variants of TNRC9 may contribute to the development of ER positive breast cancer.
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Abbreviations
- TNRC9:
-
Trinucleotide repeat-containing 9
- ER:
-
Estrogen receptor
- PR:
-
Progesterone receptor
- OR:
-
Odds-ratio
- CI:
-
Confidence interval
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Acknowledgments
We would like to thank our collaborators in the Department of General Surgery, Jiangsu Cancer Hospital (Jianwei Qin), and in the Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University (Shui Wang). This study was supported in part by the Innovative Key Grant of Department of Education (#705023); National Key Basic Research Program Grants 2002CB512908; Program for Changjiang Scholars and Innovative Research Team in University (IRT0631); and by grants from 863 program (2007AA02Z474); from One Hundred Talents Program of the Chinese Academy of Sciences, a grant from the National Nature Science Foundation (30870513), a grant (2007CB947100) from the Ministry of Science and Technology of China, a grant (08391910800) from the Science and Technology Commission of Shanghai Municipality and the Food Safety Research Center and Key Laboratory of Nutrition and Metabolism.
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Jie Liang, Peizhan Chen are the authors contributed equally to this work.
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Liang, J., Chen, P., Hu, Z. et al. Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population. Breast Cancer Res Treat 124, 237–241 (2010). https://doi.org/10.1007/s10549-010-0809-z
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DOI: https://doi.org/10.1007/s10549-010-0809-z