References
Ottini L, Palli D, Rizzo S, Federico M, Bazan V, Russo A (2010) Male breast cancer. Crit Rev Oncol Hematol 73(2):141–155
Ottini L, Rizzolo P, Zanna I, Falchetti M, Masala G, Ceccarelli K, Vezzosi V, Gulino A, Giannini G, Bianchi S, Sera F, Palli D (2009) BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy. Breast Cancer Res Treat 116(3):577–586
Rahman N, Seal S, Thompson D, Kelly P, Renwick A, Elliott A, Reid S, Spanova K, Barfoot R, Chagtai T, Jayatilake H, McGuffog L, Hanks S, Evans DG, Eccles D, Breast Cancer Susceptibility Collaboration (UK), Easton DF, Stratton MR (2007) PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat Genet 39(2):165–167
Cao AY, Huang J, Hu Z, Li WF, Ma ZL, Tang LL, Zhang B, Su FX, Zhou J, Di GH, Shen KW, Wu J, Lu JS, Luo JM, Yuan WT, Shen ZZ, Huang W, Shao ZM (2009) The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives. Breast Cancer Res Treat 114(3):457–462
Erkko H, Xia B, Nikkila J, Schleutker J, Syrjakoski K, Mannermaa A, Kallioniemi A, Pylkas K, Karppinen SM, Rapakko K, Miron A, Sheng Q, Li G, Mattila H, Bell DW, Haber DA, Grip M, Reiman M, Jukkola-Vuorinen A, Mustonen A, Kere J, Aaltonen LA, Kosma VM, Kataja V, Soini Y, Drapkin RI, Livingston DM, Winqvist R (2007) A recurrent mutation in PALB2 in Finnish cancer families. Nature 446(7133):316–319
Thellenberg C, Malmer B, Tavelin B, Grönberg H (2003) Second primary cancers in men with prostate cancer: an increased risk of male breast cancer. J Urol 169(4):1345–1348
Hemminki K, Scélo G, Boffetta P, Mellemkjaer L, Tracey E, Andersen A, Brewster DH, Pukkala E, McBride M, Kliewer EV, Chia K-S, Pompe-Kirn V, Martos C, Jonasson JG, Li X, Brennan P (2005) Second primary malignancies in patients with male breast cancer. Br J Cancer 92(7):1288–1292
Sauty de Chalon A, Teo Z, Park DJ, Odefrey FA, kConFab, Hopper JL, Southey MC (2009) Are PALB2 mutations associated with increased risk of male breast cancer? Breast Cancer Res Treat. doi:10.1007/s10549-009-0673-x
Chen P, Liang J, Wang Z, Zhou X, Chen L, Li M, Xie D, Hu Z, Shen H, Wang H (2008) Association of common PALB2 polymorphisms with breast cancer risk: a case-control study. Clin Cancer Res 14(18):5931–5937
Cao AY, Yu KD, Yin WJ, Jin W, Di GH, Shen ZZ, Shao ZM (2009) Five common single nucleotide polymorphisms in the PALB2 gene and susceptibility to breast cancer in eastern Chinese population. Breast Cancer Res Treat. doi:10.1007/s10549-009-0637-1
Acknowledgements
We wish to thank Dr. Raffaele Palmirotta and all his staff of the Department of Laboratory Medicine & Advanced Biotechnologies (IRCCS San Raffaele Pisana) for their precious suggestions and technical support. The study was supported by a grant from Associazione Italiana per la Ricerca sul Cancro (AIRC) to L.O. (IG 8713) and by Regione Toscana in the frame of the High-Risk Cancer Family Project.
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Valentina Silvestri and Piera Rizzolo equally contributed to the work.
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Silvestri, V., Rizzolo, P., Zanna, I. et al. PALB2 mutations in male breast cancer: a population-based study in Central Italy. Breast Cancer Res Treat 122, 299–301 (2010). https://doi.org/10.1007/s10549-010-0797-z
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DOI: https://doi.org/10.1007/s10549-010-0797-z