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Serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 in relation to breast cancer among Hispanic and white, non-Hispanic women in the US Southwest

  • Epidemiology
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Abstract

Insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) have been positively associated with breast cancer, especially among premenopausal women. Hispanic women have lower levels of IGF-1 and IGFBP-3 than non-Hispanic white (NHW) women, although no studies have adequately assessed the relationship among IGF-1, IGFBP-3, and breast cancer in Hispanic women. We investigated the association among IGF-1, IGFBP-3, and breast cancer within a subset of participants (n = 184 cases, 522 controls) of a population-based case–control study of women living in the U.S. Southwest. Serum levels of IGF-1 and IGFBP-3 were measured in fasting blood samples, and associations among IGF-1, IGFBP-3, and breast cancer were calculated using logistic regression, adjusting for age, study center, ethnicity, education, recent hormone exposure, body mass index, parity, total energy expenditure, total calories, and cholesterol. Both IGF-1 and IGFBP-3 were statistically significantly associated with breast cancer overall (highest vs. lowest quartile (Q4 vs. Q1) for IGF-1: odds ratio (OR) = 1.92, 95% confidence interval (CI) = 1.07–3.43); for IGFBP-3: OR = 3.04, 95% CI = 1.63–5.67). Positive associations were observed for both premenopausal breast cancer and postmenopausal breast cancer. IGF-1 was associated with breast cancer in NHW women (Q4 vs. Q1: OR = 2.82, 95% CI = 1.36–5.83), but not in Hispanic women (Q4 vs. Q1: OR = 0.81, 95% CI = 0.29–2.27). IGFBP-3 was associated with breast cancer in both ethnic groups (Q4 vs. Q1 for NHW: OR = 3.32, 95% CI = 1.45–7.60; Q4 vs. Q1 for Hispanics: OR = 2.15, 95% CI = 0.76–6.04). In conclusion, the association between IGF-1 and breast cancer differed by ethnicity, while no ethnic differences were observed in IGFBP-3-associated breast cancer.

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Acknowledgments

Financial support was provided by the National Institutes of Health (CA078682, CA078762, CA078552, and CA078802). The Utah Cancer Registry is funded by the National Cancer Institute (Contract #N01-PC-67000) with additional support from the State of Utah Department Health. The New Mexico Tumor Registry and Arizona and Colorado cancer registries are funded by the Centers for Disease Control and Prevention National Program of Cancer Registries.

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Authors and Affiliations

  1. Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center and Research Institute, Magnolia Drive, Tampa, FL, 33612, USA

    Dana E. Rollison, Anna R. Giuliano & David Boulware

  2. University of Colorado School of Medicine, Denver, CO, USA

    Betsy C. Risendal & Tim Byers

  3. Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA

    Carol Sweeney & Martha L. Slattery

  4. Don and Erika Wallace Comprehensive Breast Program, Moffitt Cancer Center, Tampa, FL, USA

    Christine Laronga

  5. Department of Epidemiology and Population Health, University of Louisville, Louisville, KY, USA

    Kathy B. Baumgartner

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  1. Dana E. Rollison
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  2. Anna R. Giuliano
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  3. Betsy C. Risendal
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  4. Carol Sweeney
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  7. Kathy B. Baumgartner
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  8. Tim Byers
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  9. Martha L. Slattery
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Correspondence to Dana E. Rollison.

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Rollison, D.E., Giuliano, A.R., Risendal, B.C. et al. Serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 in relation to breast cancer among Hispanic and white, non-Hispanic women in the US Southwest. Breast Cancer Res Treat 121, 661–669 (2010). https://doi.org/10.1007/s10549-009-0609-5

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