Breast Cancer Research and Treatment

, Volume 123, Issue 1, pp 25–34 | Cite as

The cognitive effects of chemotherapy in post-menopausal breast cancer patients: a controlled longitudinal study

  • Felice A. Tager
  • Paula S. McKinley
  • Freya R. Schnabel
  • Mahmoud El-Tamer
  • Ying Keun K. Cheung
  • Yixin Fang
  • Claire R. Golden
  • Margery E. Frosch
  • Ulya Habif
  • Margaret M. Mulligan
  • Ivy S. Chen
  • Dawn L. Hershman
Preclinical study


Studies suggest that adjuvant chemotherapy for early stage breast cancer (BC) is associated with cognitive impairment related to attention, memory, and visuospatial functioning. However, other studies have failed to confirm that relationship. We report one of the first longitudinal, controlled studies of cognitive effects of chemotherapy in older post-menopausal women. Sixty-one post-menopausal women with non-metastatic BC were administered neuropsychological tests before adjuvant therapy (Time1), six months after treatment (Time2), and at a final 6-month follow-up (Time3). Thirty women were treated with chemotherapy; thirty-one women who received no chemotherapy were controls. Cognitive domains measured included motor, language, attention/concentration/working memory, visuospatial, and memory (verbal and visual). Time-by-treatment interaction was significant in the motor domain (P = 0.007) with poorer performance in women treated with chemotherapy. For the other domains, scores did not significantly vary over time by group. In post-menopausal women, chemotherapy was not associated with changes in cognitive function in areas reported by BC survivors: attention, memory, and information processing. Motor slowing in women treated with chemotherapy could be secondary to peripheral neuropathy rather than an indication of more general declines in cognitive processing. Future studies should control for the independent effects of slowed motor functioning when looking to study possible chemotherapy related cognitive processing deficits.


Breast cancer Chemotherapy Post-menopausal Cognitive function 

Supplementary material

10549_2009_606_MOESM1_ESM.doc (32 kb)
Supplementary material 1 (DOC 32 kb)


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Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • Felice A. Tager
    • 1
    • 4
  • Paula S. McKinley
    • 1
    • 4
  • Freya R. Schnabel
    • 6
  • Mahmoud El-Tamer
    • 3
  • Ying Keun K. Cheung
    • 5
  • Yixin Fang
    • 7
  • Claire R. Golden
    • 1
  • Margery E. Frosch
    • 1
  • Ulya Habif
    • 1
  • Margaret M. Mulligan
    • 1
  • Ivy S. Chen
    • 1
  • Dawn L. Hershman
    • 2
    • 4
    • 5
  1. 1.Behavioral Medicine Program, Department of Psychiatry, College of Physicians and SurgeonsColumbia University Medical CenterNew YorkUSA
  2. 2.Department of Medicine, College of Physicians and SurgeonsColumbia University Medical CenterNew YorkUSA
  3. 3.Department of Surgical Oncology, College of Physicians and SurgeonsColumbia University Medical CenterNew YorkUSA
  4. 4.Herbert Irving Comprehensive Cancer Center, College of Physicians and SurgeonsColumbia University Medical CenterNew YorkUSA
  5. 5.Departments of Epidemiology and Biostatistics, Mailman School of Public HealthColumbia University Medical CenterNew YorkUSA
  6. 6.Department of Surgical OncologyNew York University Medical CenterNew YorkUSA
  7. 7.Department of Mathematics and StatisticsGeorgia State UniversityAtlantaGAUSA

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