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E-cadherin polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study

  • Epidemiology
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Abstract

The epithelial transmembrane glycoprotein E-cadherin (CDH1) is necessary for intercellular adhesion, cell signaling, and maintenance of cellular differentiation; reduced expression contributes to cell proliferation, invasion, and cancer progression. Functional or potentially functional single nucleotide polymorphisms (SNPs) in E-cadherin have been previously identified and evaluated in relation to cancer risk; however, studies on breast cancer have been sparse. Forty-six SNPs were genotyped to capture genetic variation of the CDH1 gene among 2,290 Phase 1 and 1,944 Phase 2 participants of the Shanghai Breast Cancer Study (SBCS), a large, population-based, case–control study. No overall associations between E-cadherin SNPs and breast cancer risk were observed. When stratified by menopausal status, associations that were consistent between Phases 1 and 2 and significant when data from both phases were combined were observed for several SNPs. Although none of these associations retained statistical significance after correcting for the total number of polymorphisms evaluated, this study suggests that genetic variation in CDH1 may be associated with breast cancer risk, and that this relationship may vary by menopausal status.

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Acknowledgments

This research was supported by USPHS grants R01CA64277, R01CA90899, and R01CA124558. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. The authors wish to thank the participants and research staff of the Shanghai Breast Cancer Study for their contributions and commitment to this project, and Brandy Venuti for assistance with the preparation of this manuscript. Sample preparation and genotyping assays, using Affymetrix arrays, were conducted at the Survey and Biospecimen Shared Resource and the Vanderbilt Microarray Shared Resource, respectively, which are supported in part by the Vanderbilt-Ingram Cancer Center (P30CA68485).

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Authors and Affiliations

  1. Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Institute of Medicine and Public Health, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 2525 West End Avenue, 8th Floor, Nashville, TN, 37203-1738, USA

    Alicia Beeghly-Fadiel, Jirong Long, Sandra L. Deming, Qiuyin Cai, Xiao-ou Shu & Wei Zheng

  2. Shanghai Center for Disease Control and Prevention, Shanghai, China

    Wei Lu & Ying Zheng

  3. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

    Yu-Tang Gao

Authors
  1. Alicia Beeghly-Fadiel
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  2. Wei Lu
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  3. Yu-Tang Gao
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  4. Jirong Long
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  5. Sandra L. Deming
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  6. Qiuyin Cai
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  7. Ying Zheng
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  8. Xiao-ou Shu
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  9. Wei Zheng
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Corresponding author

Correspondence to Wei Zheng.

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Beeghly-Fadiel, A., Lu, W., Gao, YT. et al. E-cadherin polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study. Breast Cancer Res Treat 121, 445–452 (2010). https://doi.org/10.1007/s10549-009-0579-7

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  • DOI: https://doi.org/10.1007/s10549-009-0579-7

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