Abstract
We present the case of a young lady who had been treated for acute myelocytic leukemia at the age of 14 by means of allogeneic bone marrow transplantation, the donor being her sister. At the age of 28 she underwent modified radical mastectomy for invasive breast adenocarcinoma. Genetic analysis revealed chimeric cellular populations on both the tumour and normal tissues of the patient with preponderance of donor-derived cells. We conclude that the patient’s epithelia had been repopulated by donor-derived hemopoietic stem cells which gave rise to a malignant mammary neoplasm several years later. The donor remains healthy to date. This case adds weight to the theory of pluripotent normal and neoplastic stem cell histogenesis and emphasizes the pivotal role of supporting host stroma in carcinogenesis.
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References
Jiang Y, Jahagirdar BN, Reinhardt RL et al (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41–49
Houghton J, Stoicov C, Nomura S et al (2004) Gastric cancer originating from bone marrow-derived cells. Science 306:1568–1571
Li H-C, Stoicov C, Rogers AB, Houghton J (2006) Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers. World J Gastroenterol 12:363–371
Au WY, Chan EC, Pang A et al (2004) Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring. Bone Marrow Transplant 34:981–985
Peters BA, Diaz LA, Polyak K et al (2005) Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med 11:261–262
Pardal R, Clarke FM, Morrison JS (2003) Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 3:895–902
Li F, Tiede B, Massagué J, Kang Y (2007) Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 17:3–14
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An erratum to this article can be found at http://dx.doi.org/10.1007/s10549-008-9975-7
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Golfinopouloss, V., Pentheroudakis, G., Kamakari, S. et al. Donor-derived breast cancer in a bone marrow transplantation recipient. Breast Cancer Res Treat 113, 211–213 (2009). https://doi.org/10.1007/s10549-008-9922-7
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DOI: https://doi.org/10.1007/s10549-008-9922-7