Breast cancer survivors who use estrogenic botanical supplements have lower serum estrogen levels than non users
- 96 Downloads
To measure the association between use of estrogenic botanical supplements and serum sex hormones in postmenopausal breast cancer survivors, a total 502 postmenopausal women were queried 2–3 years after breast cancer diagnosis about their use of botanical supplements, and supplements were categorized according to their estrogenic properties. Concurrently, a fasting blood sample was obtained for assay of estrone, estradiol, free estradiol, testosterone, free testosterone, dehydroepiandrosterone sulfate (DHEAS), and sex hormone-binding globulin. Adjusted means of the serum hormones were calculated by use of estrogenic supplements. Women reporting use of any estrogenic botanical supplement had significantly lower levels of estrone (20.8 vs. 23.6 pg/ml), estradiol (12.8 vs. 14.7 pg/ml), free estradiol (0.29 vs. 0.35 pg/ml), and DHEAS (47.7 vs. 56.2 µg/dl) compared to women reporting no use. Data from this cross-sectional study suggest the use of estrogenic botanical supplements may be associated with sex hormone concentrations in breast cancer survivors. Considering the high use of these supplements among breast cancer patients, further research is needed to clarify the relative estrogenicity/antiestrogenicity of these compounds and their relation with prognosis.
KeywordsBreast cancer Estrogenic botanical supplements Serum sex hormones
National Cancer Institute contracts N01-CN-75036-20, N01-CN-05228, N01-PC-67010/N01-PC-35139, N01-PC-67007/N01-PC-35138 and N01-PC-67009/N01-PC-35142, and training grant T32 CA09661. A portion of this work was conducted through the Clinical Research Center at the University of Washington and supported by the NIH grant M01-RR-00037. Data collection for the Women’s Contraceptive and Reproductive Experiences Study at the University of Southern California was supported by the National Institute of Child Health and Human Development contract N01-HD-3-3175. Patient identification was supported in part by the California Department of Health Services grant 050Q-8709-S1528. Preparation of this manuscript was supported, in part, by the University of New Mexico Cancer Center, a recipient of NCI Cancer Support Grant P30-CA118100.
- 1.Food and drug administration. Dietary Supplement Health and Education Act of 1994. [cited 2008 April 4]; Available from: http://www.fda.gov/opacom/laws/dshea.html#sec3
- 2.Trindle HA, Davis RB, Phillips RS, Eisenberg DM (2005) Trends in use of complementary and alternative medicine by US adults: 1997–2002. Altern Ther Health Med 11(1):42–49Google Scholar
- 17.Gruendwald J, Brendler T, Jaenicke C (eds) (2007) Physician’s Desk Reference for Herbal Products, 4th edn. Thompson Healthcare, Montvale, p 1300Google Scholar
- 18.Cassileth BR, Lucarelli CD (2003) Herb–drug interactions in oncology. BC Decker Inc., New YorkGoogle Scholar
- 19.Jellin JM, Gregory PJ et al. (2007) Natural medicine comprehensive database [cited 2007 11/15]; Available from: www.naturaldatabase.com
- 23.Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults (1998) Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Am J Clin Nutr 68:899–917Google Scholar
- 24.Kriska A (1997) Modifiable activity questionnaire. Med Sci Sports Exerc 29:S73–S78Google Scholar
- 32.Nettleton JA, Greany KA, Thomas W, Wangen KE, Adlercreutz H, Kurzer MS (2005) Short-term soy and probiotic supplementation does not markedly affect concentrations of reproductive hormones in postmenopausal women with and without histories of breast cancer. J Altern Complement Med 11(6):1067–1074. doi: 10.1089/acm.2005.11.1067 PubMedCrossRefGoogle Scholar
- 37.Adlercreutz H, Hockerstedt K, Bannwart C et al (1987) Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J Steroid Biochem 27(4–6):1135–1144. doi: 10.1016/0022-4731(87)90200-7 PubMedCrossRefGoogle Scholar
- 45.Beck V, Unterrieder E, Krenn L, Kubelka W, Jungbauer A (2003) Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy. J Steroid Biochem Mol Biol 84(2–3):259–268. doi: 10.1016/S0960-0760(03)00034-7 PubMedCrossRefGoogle Scholar