Skip to main content

Advertisement

SpringerLink
Log in

No association of miscarriage and BRCA carrier status in Pakistani breast/ovarian cancer patients with a history of parental consanguinity

  • Letter to the Editor
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Narod SA, Ford D, Devilee P, Barkardottir RB, Lynch HT, Smith SA, the Breast Cancer Linkage Consortium (1995) An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Am J Hum Genet 56:254–264

    PubMed  CAS  Google Scholar 

  2. Narod S, Ford D, Devilee P, Barkardottir RB, Eyfjord J, Lenoir G et al (1995) Genetic heterogeneity of breast-ovarian cancer revisited. Am J Hum Genet 57:957–958

    PubMed  CAS  Google Scholar 

  3. Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, the Breast Cancer Linkage Consortium (1998) Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet 62:676–689. doi:10.1086/301749

    Article  PubMed  CAS  Google Scholar 

  4. Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL et al (2003) Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72:1117–1130. doi:10.1086/375033

    Article  PubMed  CAS  Google Scholar 

  5. Friedman E, Bar-Sade Bruchim R, Kruglikova A, Risel S, Levy-Lahad E, Halle D et al (1998) Double heterozygotes for the Ashkenazi founder mutations in BRCA1 and BRCA2 genes. Am J Hum Genet 63:1224–1227. doi:10.1086/302040

    Article  PubMed  CAS  Google Scholar 

  6. Kuschel B, Gayther SA, Easton DF, Ponder BA, Pharoah PD (2001) Apparent human BRCA1 knockout caused by mispriming during polymerase chain reaction: implications for genetic testing. Genes Chromosomes Cancer 31:96–98. doi:10.1002/gcc.1122

    Article  PubMed  CAS  Google Scholar 

  7. Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH (1996) Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet 12:191–194. doi:10.1038/ng0296-191

    Article  PubMed  CAS  Google Scholar 

  8. Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R et al (1997) Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev 11:1242–1252. doi:10.1101/gad.11.10.1242

    Article  PubMed  CAS  Google Scholar 

  9. Gal I, Sadetzki S, Gershoni-Baruch R, Oberman B, Carp H, Papa MZ et al (2004) Offspring gender ratio and the rate of recurrent spontaneous miscarriages in Jewish women at high risk for breast/ovarian cancer. Am J Hum Genet 74:1270–1275. doi:10.1086/421442

    Article  PubMed  CAS  Google Scholar 

  10. Friedman E, Kotsopoulos J, Lubinski J, Lynch HT, Ghadirian P, Neuhausen SL, Hereditary Breast Cancer Clinical Study Group et al (2006) Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers. Breast Cancer Res 8:R15. doi:10.1186/bcr1387

    Article  PubMed  CAS  Google Scholar 

  11. Hashmi MA (1997) Frequency of consanguinity and its effect on congenital malformation—a hospital based study. J Pak Med Assoc 47:75–78

    PubMed  CAS  Google Scholar 

  12. Hussain R, Bittles AH (1998) The prevalence and demographic characteristics of consanguineous marriages in Pakistan. J Biosoc Sci 30:261–275. doi:10.1017/S0021932098002612

    Article  PubMed  CAS  Google Scholar 

  13. Rashid MU, Zaidi A, Torres D, Sultan F, Benner A, Naqvi B et al (2006) Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients. Int J Cancer 119:2832–2839. doi:10.1002/ijc.22269

    Article  PubMed  CAS  Google Scholar 

  14. World Health Organization. WHO: recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths (1977) Modifications recommended by FIGO as amended October 14, 1976. Acta Obstet Gynecol Scand 56:247–253

    Google Scholar 

  15. Abdulrazzaq YM, Bener A, al-Gazali LI, al-Khayat AI, Micallef R, Gaber T (1997) A study of possible deleterious effects of consanguinity. Clin Genet 51:167–173

    Article  PubMed  CAS  Google Scholar 

  16. Al Husain M, al Bunyan M (1997) Consanguineous marriages in a Saudi population and the effect of inbreeding on prenatal and postnatal mortality. Ann Trop Paediatr 17:155–160

    PubMed  CAS  Google Scholar 

  17. Demirel S, Kaplanoğlu N, Acar A, Bodur S, Paydak F (1997) The frequency of consanguinity in Konya, Turkey, and its medical effects. Genet Couns 8:295–301

    PubMed  CAS  Google Scholar 

  18. Bittles AH, Grant JC, Shami SA (1993) Consanguinity as a determinant of reproductive behaviour and mortality in Pakistan. Int J Epidemiol 22:463–467. doi:10.1093/ije/22.3.463

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

    Muhammad U. Rashid, Farah Rasheed & Faisal Sultan

  2. Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany

    Muhammad U. Rashid, Diana Torres & Ute Hamann

  3. University of the Punjab, Lahore, Pakistan

    Abdul R. Shakoori

  4. Blumenthal Cancer Centre, Carolinas Medical Centre, Charlotte, NC, USA

    Asim Amin

  5. Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg, Germany

    Klaus Schlaefer

Authors
  1. Muhammad U. Rashid
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Diana Torres
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Farah Rasheed
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Faisal Sultan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Abdul R. Shakoori
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Asim Amin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Klaus Schlaefer
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ute Hamann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ute Hamann.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rashid, M.U., Torres, D., Rasheed, F. et al. No association of miscarriage and BRCA carrier status in Pakistani breast/ovarian cancer patients with a history of parental consanguinity. Breast Cancer Res Treat 116, 211–213 (2009). https://doi.org/10.1007/s10549-008-0095-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10549-008-0095-1

Keywords

Search

Navigation