Skip to main content

Advertisement

SpringerLink
Log in

Link between insulin and metabolic disorders in cancer: does leptin play a key role?

  • Letter to the Editor
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Goodwin PJ, Ennis M, Bahl M et al. (2008) High insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome. Breast Cancer Res Treat. doi:10.1007/s10549-008-0019-0

  2. Capristo E, Malandrino N, Farnetti S et al (2006) Metabolic alterations as a risk factor for cancer. Intern Emerg Med 1:29S–35S

    Google Scholar 

  3. Malmström R, Taskinen MR, Karonen SL et al (1996) Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 39:993–996. doi:10.1007/BF00403921

    Article  PubMed  Google Scholar 

  4. Mueller WM, Gregoire FM, Stanhope KL et al (1998) Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 139:551–558. doi:10.1210/en.139.2.551

    Article  PubMed  CAS  Google Scholar 

  5. Greco AV, Mingrone G, Vettor R et al (2002) Lowering of circulating free-fatty acids levels and reduced expression of leptin in white adipose tissue in post-obesity status. J Investig Med 50:207–213. doi:10.2310/6650.2002.33435

    Article  PubMed  CAS  Google Scholar 

  6. Perera CN, Spalding HS, Mohammed SI et al (2008) Identification of proteins secreted from leptin stimulated mcf-7 breast cancer cells: a dual proteomic approach. Exp Biol Med 233:708–720. doi:10.3181/0710-RM-281

    Article  CAS  Google Scholar 

  7. Slattery ML, Wolff RK, Herrick J et al (2008) Leptin and leptin receptor genotypes and colon cancer: gene–gene and gene-lifestyle interactions. Int J Cancer 122:1611–1617. doi:10.1002/ijc.23135

    Article  PubMed  CAS  Google Scholar 

  8. Stattin P, Söderberg S, Hallmans G et al (2001) Leptin is associated with increased prostate cancer risk: a nested case-referent study. J Clin Endocrinol Metab 86:1341–1345. doi:10.1210/jc.86.3.1341

    Article  PubMed  CAS  Google Scholar 

  9. Ramani K, Yang H, Xia M et al (2008) Leptin’s mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta. Hepatology 47:521–531. doi:10.1002/hep.22064

    Article  PubMed  CAS  Google Scholar 

  10. Koda M, Sulkowska M, Kanczuga-Koda L et al (2007) Expression of leptin and its receptor in female breast cancer in relation with selected apoptotic markers. Folia Histochem Cytobiol 45:S187–S191

    PubMed  Google Scholar 

  11. Soma D, Kitayama J, Yamashita H et al. (2007) Leptin augments proliferation of breast cancer cells via transactivation of HER2. J Surg Res. doi:10.1016/j.jss.2007.10.012

Download references

Author information

Authors and Affiliations

  1. Institute of Internal Medicine, Metabolic Unit, Catholic University of Rome, Largo A. Gemelli 8, 00168, Rome, Italy

    Noemi Malandrino & Esmeralda Capristo

  2. Institute of Internal Medicine, Catholic University of Rome, Largo A. Gemelli 8, 00168, Rome, Italy

    Lorenzo Leggio, Giovanni Addolorato & Giovanni Gasbarrini

Authors
  1. Noemi Malandrino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lorenzo Leggio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Giovanni Addolorato
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Giovanni Gasbarrini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Esmeralda Capristo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Noemi Malandrino.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Malandrino, N., Leggio, L., Addolorato, G. et al. Link between insulin and metabolic disorders in cancer: does leptin play a key role?. Breast Cancer Res Treat 115, 435–436 (2009). https://doi.org/10.1007/s10549-008-0091-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10549-008-0091-5

Keywords

Search

Navigation