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Oncological and aesthetic considerations of skin-sparing mastectomy

Breast Cancer Research and Treatment volume 111, pages 391–403 (2008)Cite this article

Abstract

Aim To review the oncological safety and aesthetic value of skin-sparing mastectomy (SSM) for invasive breast cancer (IBC) and ductal carcinoma in-situ (DCIS). Controversies including the impact of radiotherapy (RT) on immediate breast reconstruction (IBR), preservation of the nipple-areola complex (NAC) and the role of endoscopic mastectomy are also considered. Methods Literature review facilitated by Medline and PubMed databases. Results SSM is an oncologically safe technique in selected cases, including IBC <5 cm, multi-centric tumours, DCIS and prophylactic risk-reduction surgery. The high risk of local recurrence (LR) excludes inflammatory breast cancers and tumours with extensive involvement of the skin. SSM can facilitate IBR and is associated with an excellent aesthetic result. Prior breast irradiation or the need for post-mastectomy radiotherapy (PMR) do not preclude SSM, however the cosmetic outcome may be affected. Nipple/areola preservation is possible for remote tumours, employing a frozen section protocol for the retro-areolar tissue. There is limited data available for endoscopic mastectomy and superiority over conventional SSM has not been established. Conclusion In appropriately selected cases SSM is oncologically adequate. There are several patient centred advantages over conventional mastectomy, including aesthetic outcome and the avoidance of multiple staged procedures. Despite widespread uptake into surgical practice, validation of these techniques from randomised controlled trials is lacking.

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Affiliations

  1. London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London, W1U 5NY, UK

    Neill Patani & Kefah Mokbel

  2. St. George’s University of London, London, UK

    Kefah Mokbel

Authors
  1. Neill Patani
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  2. Kefah Mokbel
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Correspondence to Kefah Mokbel.

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Patani, N., Mokbel, K. Oncological and aesthetic considerations of skin-sparing mastectomy. Breast Cancer Res Treat 111, 391–403 (2008). https://doi.org/10.1007/s10549-007-9801-7

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  • DOI: https://doi.org/10.1007/s10549-007-9801-7

Keywords

  • Aesthetic
  • Breast cancer
  • Ductal carcinoma in-situ
  • Evidence
  • Morbidity
  • Mortality
  • Nipple/Areola sparing mastectomy
  • Oncological safety
  • Radiotherapy
  • Recurrence
  • Skin-sparing Mastectomy