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Active and passive smoking, IL6, ESR1, and breast cancer risk

  • Epidemiology
  • Published:
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Abstract

We evaluated the association between smoking and risk of breast cancer in non-Hispanic white (NHW) and Hispanic or American Indian (HAI) women living in the Southwestern United States. Data on lifetime exposure to active and passive smoke data were available from 1527 NHW cases and 1601 NHW controls; 798 HAI cases and 924 HAI controls. Interleukin 6 (IL6) and Estrogen Receptor alpha (ESR1) polymorphisms were assessed in conjunction with smoking. Pack-years of smoking (≥15) were associated with increased risk of pre-menopausal breast cancer among NHW women (OR 1.6, 95% CI 1.1–2. 4). Passive smoke increased risk of pre-menopausal breast cancer for HAI women (OR 1.9, 95% CI 1.1–3.1 everyone; OR 2.3, 95% CI 1.2–4.5 nonsmokers). HAI pre-menopausal women who were exposed to 10+ h of passive smoke per week and had the rs2069832 IL6 GG genotype had over a fourfold increased risk of breast cancer (OR 4.4, 95% CI 1.5–12.8; P for interaction 0.01). Those with the ESR1 Xba1 AA genotype had a threefold increased risk of breast cancer if they smoked ≥15 pack-years relative to non-smokers (P interaction 0.01). These data suggest that breast cancer risk is associated with active and passive smoking.

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Acknowledgements

This study was funded by CA 078682, CA 078762, CA078552, CA078802. This research was supported by the Utah Cancer Registry, which is funded by Contract #N01-PC-67000 from the National Cancer Institute, with additional support from the State of Utah Department of Health, the New Mexico Tumor Registry and the Arizona and Colorado cancer registries, funded by the Centers for Disease Control and Prevention National Program of Cancer Registries and additional state support. We would like to acknowledge the contributions of Roger Edwards, Jennifer Herrick, Leslie Palmer, Betsy Risendal, Tara Patton, Jason Witter, and Kelly May to this study.

The contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the official view of the National Cancer Institute.

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Authors and Affiliations

  1. Division of Epidemiology, Department of Medicine, University of Utah, Salt Lake City, UT, 84117, USA

    Martha L. Slattery, Karen Curtin, Carol Sweeney, Sandra Edwards & Roger K. Wolff

  2. Moffitt Cancer Center, Tampa, FL, USA

    Anna R. Giuliano

  3. Department of Epidemiology and Population Health, University of Louisville, Louisville, KY, USA

    Richard Baumgartner & Kathy B. Baumgartner

  4. University of Colorado School of Medicine, Denver, CO, USA

    Tim Byers

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  1. Martha L. Slattery
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  2. Karen Curtin
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Correspondence to Martha L. Slattery.

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Slattery, M.L., Curtin, K., Giuliano, A.R. et al. Active and passive smoking, IL6, ESR1, and breast cancer risk. Breast Cancer Res Treat 109, 101–111 (2008). https://doi.org/10.1007/s10549-007-9629-1

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  • DOI: https://doi.org/10.1007/s10549-007-9629-1

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