Skip to main content

Association between early-onset breast and laryngeal cancers

Breast Cancer Research and Treatment volume 97, pages 215–219 (2006)Cite this article

Summary

Recent studies suggest that there are groups of genes that predispose simultaneously to both early-onset breast and laryngeal cancer. Studies were performed on a large series of unselected patients with laryngeal cancer diagnosed in Szczecin, Poland. Pedigrees of 683 laryngeal cancer patients were analysed for the frequency of early-onset and late-onset breast cancer among first degree relatives. The observed frequencies of breast cancer in these families were compared to those expected. In addition, common mutations/variants in the 3 genes BRCA1, NOD2 and CYP1B1, known to be associated with early-onset breast cancer, were assessed to determine their frequency in 348 unselected laryngeal cancers. The average age at diagnosis of LC among patients, who had relatives affected by BC diagnosed under the age of 50 years was 57.62. In comparison LC patients reporting a first degree relative affected by BC diagnosed above 50 years of age, had an average age of diagnosis of 66.00 years, which was significantly different (p=0.0064). Similarly, the average age of diagnosis of BC among patients with LC diagnosed under age of 50 years was 46.7 years and whereas LC patients with tumors diagnosed above 50 years had relatives diagnosed with breast cancer at an average age of 53.37 years, which was significantly different (p=0.02).

From the 348 consecutive ascertained laryngeal cancer patients who had molecular studies undertaken, breast cancers among first degree relatives were found in 18 families including 8 with breast cancers diagnosed less than 50 years of age. A molecular basis was identified (the CYP1B1 355T/T genotype) in only 2 of the 8 early cases suggestive of there being additional, as yet unknown genes that are associated with an early-onset laryngeal-breast cancer phenotype.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. Easton DF, Steele L, Fields P, Ormiston W, Averill D, Daly PA, McManus R, SL Neuhausen, Ford D, Wooster R, Cannon-Albright L, Stratton MR, Goldgar DE., 1997 Cancer risks in two large breast cancer families linked to BRCA2 on chromosome 13q12–13 Am J Hum Genet 61: 120–128

    PubMed  Article  CAS  Google Scholar 

  2. Shimada T, Hayes CL, Yamazaki H, Amin S, Hecht SS, Guengerich FP, Sutter TR, 1996 Activation of chemically diverse procarcinogens by human cytochrom P-450 1B1 Cancer Res 56: 2979–2984

    PubMed  CAS  Google Scholar 

  3. Tsuchiya Y, Nakajima M, Kyo S, Kanaya T, Inoue M, T. Yokoi, 2004 Human CYP1B1 is regulated by estradiol via estrogen receptor.Cancer Res 64: 3119–3125

    CAS  Google Scholar 

  4. Watanabe J, Shimada T, Gillam EM, Ikuta T, Suemasu K, Higashi Y, Gotoh O, Kawajiri K, 2000 Association of CYP1B1 genetic polimorphism with incidence to breast and lung cancer Pharmacogenetics 10: 25–33

    PubMed  Article  CAS  Google Scholar 

  5. Murray GI, Taylor MC, McFadyen MC, McKay JA, Greenlee WF, Burke MD, Melvin WT, 1997 Tumor – specific expression of cytochrom P450 CYP1B1 Cancer Res. 57: 3026–3031

    PubMed  CAS  Google Scholar 

  6. Han X, Liehr JG, 1994 8-Hydroxylation o guanine bases in kidney and liver DNA of hamsters treated with estradiol: role o free radials in estrogen-induced carcinogenesis Cancer Res 54: 5515–5517

    PubMed  CAS  Google Scholar 

  7. Han X, Liehr JG, 1994 DNA single-strand breaks in kidneys of Syrian hamsters treated with steroidal estrogen- inducted free radial damage preceding renal malignancy Carcinogenesis 15: 997–1000

    PubMed  Article  CAS  Google Scholar 

  8. Huzarski T, Lener M, Domagała W, Gronwald J, Byrski T, Kurzawski G, Suchy J, Chosia M, Woyton J, Ucinski M, Narod SA,Lubiński J., 2005 The 3020insC allele of NOD2 predisposes to early-onset breast cancer Breast Cancer Res Treat 89: 91–93

    PubMed  Article  Google Scholar 

  9. Lubiński J, Huzarski T, Kurzawski G, Suchy J, Masojć B, Mierzejewski M, Lener M, Domagała W, Chosia M, Teodorczyk U, Mędrek K, Dębniak T, Złowocka E, Gronwald J, Byrski T, Grabowska E, Nej K, Szymańska A, Szymańska J, Matyjasik J, Cybulski C, Jakubowska A, Górski B, Narod S.A., 2005 The 3020insC allele of NOD2 predisposes to cancers of multiple organs Hereditary Cancer Clin Practice 3: 59–63

    Google Scholar 

  10. Lahiri DK, Jr Nurnberger JI, 1991 A rapid non-enzymatic method for the preparation of HMW DNA blood for RFLP studies Nucleic Acids Res 19: 5444

    PubMed  Article  CAS  Google Scholar 

  11. Gorski B, Cybulski C, Huzarski T, Byrski T, Gronwald J, Jakubowska A, Stawicka M, Gozdecka-Grodecka S, Szwiec M, Urbansi K, Mitus J, Marczyk E, Dziuba J, Wandzel P, Surdyka D, Haus O, Janiszewska H, Debniak T, Toloczko-Grabarek A, Medrek K, Masojc B, Mierzejewski M, Kowalska E, Narod SA, Lubinski J: Breast cancer predisposing alleles in Poland. Breast Cancer Res Treat 92: 19–24, 2005

    Google Scholar 

  12. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Morgan T, Karaliuskas R, Duerr RH, Achkar JP, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH, 2001 A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease Nature 411: 603–606

    PubMed  Article  CAS  Google Scholar 

  13. Górski B, Byrski T, Huzarski T, Jakubowska A, Menkiszak J, Gronwald J, Płużańska A, Bębenek M, Fischer-Maliszewska Ł, Grzybowska E, Narod SA, Lubiński J, 2000 Founder Mutation in the BRCA1 Gene in Polish Families with Breast-Ovarian Cancer Am J Genet 66: 1963–1968

    Article  Google Scholar 

  14. van Asperen CJ, Brohet RM, Meijers-Heijboer EJ, Hoogerbrugge N, Verhoef S, Vasen HF, Ausems MG, Menko FH, Gomez Garcia EB, Klijn JG, Hogervorst FB, van Houwelingen JC, van’t Veer LJ, Rookus MA, van Leeuwen FE, 2005 Netherlands Collaborative Group on Hereditary Breast Cancer (HEBON). Cancer risks in BRCA2 families: estimates for sites other than breast and ovary J Med Genet 42: 711–719

    PubMed  Article  Google Scholar 

  15. Jakubowska A, Nej K, Huzarski T, Scott RJ, Lubinski J, 2002 BRCA2 gene mutations in families with aggregations of breast and stomach cancers Br J Cancer 87: 888–891

    PubMed  Article  CAS  Google Scholar 

  16. Braga C, Negri E, La Vecchia C, Filiberti R, Franceschi S, 1996 Cigarette smoking and risk of breast cancer Eur J Cancer Prev 5: 159–164

    PubMed  Article  CAS  Google Scholar 

  17. Ghadirian P, Lubinski J, Lynch H, Neuhausen SL, Weber B, Isaacs C, Baruch RG, Randal S, Ainsworth P, Friedman E, Horsman D, Tonin P, Foulkes WD, Tung N, Sun P, Narod SA, 2004 Smoking and the risk of breast cancer among carriers of BRCA mutations Int J Cancer 110: 413–416

    PubMed  Article  CAS  Google Scholar 

  18. Terry PD, Rohan TE., 2002 Cigarette smoking and the risk o breast cancer in women: a review of the literature Cancer Epidemiol Biomarkers Prev 11: 953–971

    PubMed  Google Scholar 

  19. Baron JA, La Vecchia C, Levi F, 1990 The anti estrogenic effect or cigarette smoking in women Am J Obest Gynecol 162: 502–514

    CAS  Google Scholar 

Download references

Author information

Affiliations

  1. Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland

    Ewa Jaworowska, Czesława Tarnowska & Katarzyna Amernik

  2. International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

    Bartłomiej Masojć, Pablo Serrano-Fernandez, Joanna Matyjasik & Jan Lubiński

  3. Department of Reumatology, Pomeranian Medical University, Szczecin, Poland

    Marek Brzosko &  Jacek Fliciński

  4. Discipline of Medical Genetics, Faculty of Health, University of Newcastle, and the Hunter Medical Research Institute, Newcastle, NSW, Australia

    Rodney J. Scott

  5. Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252, Szczecin, Poland

    Ewa Jaworowska

Authors
  1. Ewa Jaworowska
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bartłomiej Masojć
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Czesława Tarnowska
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Marek Brzosko
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jacek Fliciński
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Pablo Serrano-Fernandez
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Joanna Matyjasik
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Katarzyna Amernik
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Rodney J. Scott
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Jan Lubiński
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ewa Jaworowska.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Jaworowska, E., Masojć, B., Tarnowska, C. et al. Association between early-onset breast and laryngeal cancers. Breast Cancer Res Treat 97, 215–219 (2006). https://doi.org/10.1007/s10549-005-9116-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10549-005-9116-5

Keywords

  • breast and larynx cancer
  • CYP1B1
  • NOD2