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Ductal Breast Carcinomas with Whole Chromosome Gains as a Particular Subset of Near-Diploid Tumors with Different Metastasis Free Survival

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Summary

We recently proposed the existence of a subtype of slightly hyperdiploid ductal breast cancers with cytogenetic alterations differing from those usually observed in the majority of these tumors. We aimed to establish whether these tumors, which represent about 50% of those with a DNA index (DI) comprised between 1.1 and 1.3, correspond to a particular clinicopathological entity. A retrospective study of 1771 patients operated for ductal carcinomas was performed. Three classes of tumors constituted according to DI were compared for the usual clinicopathological factors and clinical outcome. About 690 tumors (39%) were diploid/hypodiploid (DI  < 1.1), 134 (7.6%) were hyperdiploid (1.1 ≤ DI  < 1.3) and 947 (53.4%) were polyploid (DI  ≥ 1.3). Median follow-up time was 106 months (range 1–177). Polyploid tumors were significantly associated with large tumor size, advanced clinical stage, high histological grade and S-phase fraction (SPF), positive lymph nodes and loss of steroid receptors. Hyperdiploid and diploid/hypodiploid tumors were similar for all the variables except SPF which was significantly higher in hyperdiploid tumors (p < 0.001). Overall survival was similar in hyperdiploid and diploid/hypodiploid tumors in univariate and multivariate analysis, while hyperdiploid tumors were significantly related to a poorer metastasis free survival, both in univariate (p = 0.023) and multivariate analysis (p = 0.031). Despite very close initial clinicopathological and biological characteristics, hyperdiploid tumors differed from diploid/hypodiploid tumors by a higher risk of metastasis, possibly related to their increased SPF.

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Abbreviations

CGH:

comparative genomic hybridization

DI:

DNA index

ER:

estrogen receptor

HR:

hazard ratio

MFS:

metastasis free survival

NCA:

numerical chromosome aberrations

OS:

overall survival

PR:

progesterone receptor

SCA:

structural chromosome aberrations

SPF:

S-phase fraction

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Authors and Affiliations

  1. Service de biostatistique, Institut Curie, Paris, France

    Caroline Elie & Bernard Asselain

  2. FRE 2584 CNRS, Institut Curie, Paris, France

    Romain Molist, Bernard Dutrillaux & Martine Muleris

  3. CEPH, INSERM U434, 27 rue Juliette Dodu, 75010, Paris, France

    Martine Muleris

Authors
  1. Caroline Elie
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  2. Romain Molist
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  3. Bernard Asselain
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  4. Bernard Dutrillaux
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  5. Martine Muleris
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Correspondence to Martine Muleris.

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Elie, C., Molist, R., Asselain, B. et al. Ductal Breast Carcinomas with Whole Chromosome Gains as a Particular Subset of Near-Diploid Tumors with Different Metastasis Free Survival. Breast Cancer Res Treat 92, 279–285 (2005). https://doi.org/10.1007/s10549-005-3379-8

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