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Breast Cancer Research and Treatment

, Volume 94, Issue 2, pp 105–109 | Cite as

Polymorphisms of the BRCA2 and RAD51 Genes in Breast Cancer

  • Tomasz Sliwinski
  • Renata Krupa
  • Ireneusz Majsterek
  • Jan Rykala
  • Agnieszka Kolacinska
  • Zbigniew Morawiec
  • Jozef Drzewoski
  • Marek Zadrozny
  • Janusz BlasiakEmail author
Report

Summary

We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR–RFLP. Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homozygous polymorphic variants, whereas heterozygous variant was associated with significant reduction in breast cancer risk. Gene-gene interaction between the BRCA2-Met1915Thr Thr/Thr and BRCA2-Met784Val Met/Met homozygous variants increased the risk. Therefore, the Met1915Thr polymorphism in the BRCA2 gene may be considered as an independent marker of breast cancer.

Keywords

BRCA2 breast cancer DNA repair gene polymorphism RAD51 

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Copyright information

© Springer 2005

Authors and Affiliations

  • Tomasz Sliwinski
    • 1
  • Renata Krupa
    • 1
  • Ireneusz Majsterek
    • 1
  • Jan Rykala
    • 2
  • Agnieszka Kolacinska
    • 2
  • Zbigniew Morawiec
    • 2
  • Jozef Drzewoski
    • 3
  • Marek Zadrozny
    • 4
  • Janusz Blasiak
    • 1
    Email author
  1. 1.Department of Molecular GeneticsUniversity of LodzLodzPoland
  2. 2.N. Copernicus HospitalLodzPoland
  3. 3.Department of Clinical PharmacologyMedical University of LodzLodzPoland
  4. 4.Polish Mother’s Memorial HospitalLodzPoland

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