Abstract
Purpose.Being at hereditary risk of breast cancer (BC) may lead to elevated levels of distress because of the impact of the BC-process in relatives.
Objective.Determine the association between psychological distress and BC in relatives. We studied: kind of kinship with the affected relative(s), degree of involvement with the relative’s BC, time elapsed since the BC diagnosis of the relative, and loss of a relative as a consequence of BC.
Methods.The study cohort consisted of women at increased risk of developing BC, adhering to regular surveillance and participating in the Dutch MRISC-study. Two months prior to the surveillance appointment, demographics, general and BC specific distress and experience with BC in the family were assessed.
Results.347 out of 351 participants (mean age 40 1/2) had at least one relative affected with BC. The following variables were significantly, positively related to BC specific distress: having at least one affected sister (n=105; p < 0.04); close involvement in a sister’s BC process (n=94; p < 0.03); and a recent (less than three years ago) BC diagnosis in a sister (n=30; p < 0.03). General distress did not show any significant associations with the experience of BC in the family.
Conclusion. These findings show the impact of a BC diagnosis in a sister, particularly a recent diagnosis, on psychological distress. Women who have experienced BC in their sister may be in need of additional counselling or of more attention during the surveillance process.
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References
KM Kash JC Holland MS Halper et al. (1992) ArticleTitlePsychological distress and surveillance behaviors of women with a family history of breast cancer J Natl Cancer Inst 84 24–30 Occurrence Handle1738170 Occurrence Handle1:STN:280:By2C2cfosVI%3D
C Lerman M Schwartz (1993) ArticleTitleAdherence and psychological adjustment among women at high risk for breast cancer Breast Cancer Res Treat 28 145–155 Occurrence Handle8173067 Occurrence Handle1:STN:280:ByuB38jitlI%3D
C Lerman M Daly C Sands et al. (1993) ArticleTitleMammography adherence and psychological distress among women at risk for breast cancer J Natl Cancer Inst 85 1074–1080 Occurrence Handle8515494 Occurrence Handle1:STN:280:ByyB1MvovFQ%3D
C Lerman K Kash M Stefanek (1994) ArticleTitleYounger women at increased risk for breast cancer: perceived risk, psychological well-being, and surveillance behavior J Natl Cancer Inst Monogr 16 171–176 Occurrence Handle7999461
S Lloyd M Watson B Waites et al. (1996) ArticleTitleFamilial breast cancer: a controlled study of risk perception, psychological morbidity and health beliefs in women attending for genetic counselling Br J Cancer 74 482–487 Occurrence Handle8695370 Occurrence Handle1:STN:280:BymA3MnoslA%3D
SG Zakowski HB Valdimarsdottir DH Bovbjerg et al. (1997) ArticleTitlePredictors of intrusive thoughts and avoidance in women with family histories of breast cancer Ann Behav Med 19 362–369 Occurrence Handle10.1007/BF02895155 Occurrence Handle9706363 Occurrence Handle1:STN:280:DyaK1czntFKmsA%3D%3D
DK Wellisch ER Gritz W Schain et al. (1992) ArticleTitlePsychological functioning of daughters of breast cancer patients. Part II: Characterizing the distressed daughter of the breast cancer patient. Psychosomatics 33 171–179 Occurrence Handle1557482 Occurrence Handle1:STN:280:By2B3Mzhs1U%3D
P Hopwood A Shenton F Lalloo et al. (2001) ArticleTitleRisk perception and cancer worry: an exploratory study of the impact of genetic risk counselling in women with a family history of breast cancer. J Med Genet 38 139 Occurrence Handle11288719 Occurrence Handle1:STN:280:DC%2BD3M7psFKmtA%3D%3D
J Erblich DH Bovbjerg HB Valdimarsdottir (2000) ArticleTitleLooking forward and back: distress among women at familial risk for breast cancer Ann Behav Med 22 53–59 Occurrence Handle10892528 Occurrence Handle1:STN:280:DC%2BD3M%2FitVSnsg%3D%3D
B Meiser P Butow V Schnieden (2000) ArticleTitlePsychological adjustment of women at increased risk of developing hereditary breast cancer Psychol Health Med 5 377–389
M Kriege CTM Brekelmans C Boetes et al. (2001) ArticleTitleMRI screening for breast cancer in women with familial or genetic predisposition: design of the Dutch National Study (MRISC) Familial Cancer 1 163–168 Occurrence Handle14574173 Occurrence Handle1:STN:280:DC%2BD3svps1Smsg%3D%3D
EB Claus N Risch WD Thompson (1994) ArticleTitleAutosomal dominant inheritance of early-onset breast cancer. Implications for risk prediction. Cancer 73 643–651 Occurrence Handle8299086 Occurrence Handle1:STN:280:ByuC3s%2Fitlw%3D
CT Brekelmans AC Voogd G Botke et al. (1999) ArticleTitleFamily history of breast cancer and local recurrence after breast-conserving therapy. The Dutch Study Group on Local Recurrence after Breast Conservation (BORST). Eur J Cancer 35 620–626 Occurrence Handle10492637 Occurrence Handle1:STN:280:DyaK1Mvit1ejtw%3D%3D
CT Brekelmans C Seynaeve CC Bartels et al. (2001) ArticleTitleEffectiveness of breast cancer surveillance in BRCA1/2 gene mutation carriers and women with high familial risk J Clin Oncol 19 924–930 Occurrence Handle11181654 Occurrence Handle1:STN:280:DC%2BD3M3gsFamtg%3D%3D
M Horowitz N Wilner W Alvarez (1979) ArticleTitleImpact of Event Scale: a measure of subjective stress Psychosom Med 41 209–218 Occurrence Handle1:STN:280:CSaB2cjltVw%3D Occurrence Handle472086
AS Zigmond RP Snaith (1983) ArticleTitleThe hospital anxiety and depression scale Acta Psychiatr Scand 67 361–370 Occurrence Handle1:STN:280:BiyB2sbhtVw%3D Occurrence Handle6880820
LR Derogatis RS Lipman L Covi (1973) ArticleTitleSCL-90: an outpatient psychiatric rating scale–preliminary report Psychopharmacol Bull 9 13–28 Occurrence Handle4682398 Occurrence Handle1:STN:280:CSyD28rjvFI%3D
van Dooren S, Rijnsburger AJ, Seynaeve C et al.: Psychological distress in women at increased risk for breast cancer: the role of risk perception. Eur J Cancer in press.
van Dooren S, Rijnsburger AJ, Seynaeve C et al.: Psychological distress and breast self examination frequency in women at increased risk for breast cancer. Commun Genet in press.
P Hopwood (2000) ArticleTitleBreast cancer risk perception: what do we know and understand Breast Cancer Res 2 387–391 Occurrence Handle11250730 Occurrence Handle1:STN:280:DC%2BD3MvgvFShsg%3D%3D
A Dudok-de Wit A Tibben H. Duivenvoorden et al. (1997) ArticleTitlePsychological distress in applicants for predictive DNA-testing for autosomal, dominant, heritable, late onset disorders J Med Genet 34 382–390 Occurrence Handle1:STN:280:ByiB1Mjjs1I%3D Occurrence Handle10.1136/jmg.34.5.382
LN Lodder PG Frets RW Trijsburg et al. (1999) ArticleTitlePresymptomatic testing for BRCA1 and BRCA2: how distressing are the pre-test weeks? Rotterdam/Leiden Genetics Working Group. J Med Genet 36 906–913 Occurrence Handle10593998 Occurrence Handle1:STN:280:DC%2BD3c%2FmtlSjsQ%3D%3D
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Dooren, S.v., Seynaeve, C., Rijnsburger, A.J. et al. The impact of having relatives affected with breast cancer on psychological distress in women at increased risk for hereditary breast cancer. Breast Cancer Res Treat 89, 75–80 (2005). https://doi.org/10.1007/s10549-004-2623-y
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DOI: https://doi.org/10.1007/s10549-004-2623-y