Dual-site rTMS is More Effective than Single-site rTMS in Tinnitus Patients: A Blinded Randomized Controlled Trial

Noh, Tae-Soo; Kyong, Jeong-Sug; Park, Moo Kyun; Lee, Jun Ho; Oh, Seung Ha; Suh, Myung-Whan

doi:10.1007/s10548-020-00797-y

Original Paper
Published: 17 September 2020

Dual-site rTMS is More Effective than Single-site rTMS in Tinnitus Patients: A Blinded Randomized Controlled Trial

Tae-Soo Noh¹^na1,
Jeong-Sug Kyong²^na1,
Moo Kyun Park¹,
Jun Ho Lee¹,
Seung Ha Oh¹ &
Myung-Whan Suh ORCID: orcid.org/0000-0003-1301-2249¹

Brain Topography volume 33, pages 767–775 (2020)Cite this article

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) has been proposed as an alternative option for treating tinnitus. rTMS is a noninvasive method in which repetitive magnetic stimulation is applied to the cortex; it is considered a therapeutic strategy that modulates the loudness of tinnitus. In this study, we performed a double-blind randomized clinical trial to compare the outcome of tinnitus treatment among (1) dual-site (auditory + prefrontal) rTMS stimulation, (2) auditory cortex only rTMS stimulation (AC), and (3) sham stimulation. The left primary auditory cortex and left dorsolateral prefrontal cortex (DLPFC) were targeted independently of handedness or tinnitus laterality. Dual-site and auditory only groups were treated with a total of 12,000 pulses, 2000 pulses over the AC and 1000 pulses over the DLPFC (group 1), 3000 pulses over the AC only (group 2), and daily for 4 consecutive days. Dual-site group exhibited a significantly better ΔTinnitus Handicap Inventory (ΔTHI) score at 4, 8 weeks and 12 weeks after rTMS treatments compared with pre-treatment. However, there was no effect in the auditory only group. Also, there was no effect in sham group when THI scores were compared with that of the pre-treatment. These results are in line with the former studies that reported a better treatment effect by multiple site rTMS.

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Funding

This research was supported by the Korea Health Industry Development Institute (KHDI) of Korean Ministry of Health and Welfare (Grant No. HI18C0626).

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Tae-Soo Noh and Jeong-Sug Kyong have equally contributed to this work.

Authors and Affiliations

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul National University College of medicine, Yongon-Dong, Chongno-Gu, Seoul, 110-744, Korea
Tae-Soo Noh, Moo Kyun Park, Jun Ho Lee, Seung Ha Oh & Myung-Whan Suh
Department of Audiology and Speech-Language Pathology, Audiology Institute, Hallym University of Graduate Studies, Seoul, Korea
Jeong-Sug Kyong

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Tae-Soo Noh
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Jeong-Sug Kyong
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Moo Kyun Park
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Jun Ho Lee
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Seung Ha Oh
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Myung-Whan Suh
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Correspondence to Myung-Whan Suh.

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The present study was approved by the institutional review board at Seoul National University Hospital (1212-081-451) and was conducted according to the tenets of the Declaration of Helsinki. This study had been previously registered at Clinical Trials on May 28, 2013 (NCT01886092). All study procedure was done in accordance with approved guidelines.

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Noh, TS., Kyong, JS., Park, M.K. et al. Dual-site rTMS is More Effective than Single-site rTMS in Tinnitus Patients: A Blinded Randomized Controlled Trial. Brain Topogr 33, 767–775 (2020). https://doi.org/10.1007/s10548-020-00797-y

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Received: 27 March 2020
Accepted: 09 September 2020
Published: 17 September 2020
Issue Date: November 2020
DOI: https://doi.org/10.1007/s10548-020-00797-y

Keywords

Tinnitus
Transcranial magnetic stimulation
Auditory Cortex
Prefrontal cortex