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Neuropsychological Deficits in Patients with Electrical Status Epilepticus During Sleep: A Non-invasive Analysis of Neurovascular Coupling

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Abstract

To evaluate the effects of electrical status epilepticus during sleep (ESES) on cerebral blood flow (CBF) and explore the associated neuro-vascular coupling and neuropsychological deficits. 19 ESES patients were recruited to undergo real-time transcranial doppler ultrasonography (TCD) and video-EEG monitoring (vEEG). Patients were grouped based on their cognitive functions or their EEG patterns. The mean cerebral blood flow velocity (CBFVm) of the unilateral middle cerebral artery was measured using TCD and was used to calculate various relevant parameters. The 19 patients participated in a total of 54 effective TCD–vEEG monitoring sessions. We found a significant effect of clinical severity for the following measurements: spike wave index (SWI), peak and average deep sleep stage (N3) CBFVm, peak, average and minimum deep sleep and awake CBFVm, and CBFVm oscillations during deep sleep. Nevertheless, CBFVm oscillations were not related to SWI. Furthermore, CBFVm oscillations revealed a statistically significant difference between the near-ESES and asymmetric-ESES groups. CBFVm oscillations may reflect the neuro-vascular coupling process associated with ESES disfunction. Understanding the relationship between CBFVm oscillations and epileptic activity will be important for assessing the neuropsychological damage associated with ESES and for developing treatment options for this and other diseases.

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Acknowledgements

We would like to extend our deepest appreciation to the patients and their families receiving care in Guangzhou Women and Children’s Medical Center. We would also like to thank China Association Against Epilepsy (CAAE) and UCB. This study was supported in part by the Research Fund of CAAE-UCB Fund.

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Authors and Affiliations

  1. Department of Neurology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 318# Ren Min Road, Guangzhou, Guangdong, 510120, P.R. China

    Bingwei Peng, Jialing Li, Xiaojing Li, Xiuying Wang, Haixia Zhu, Wei Liang, Huici Liang & Wenxiong Chen

Authors
  1. Bingwei Peng
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  2. Jialing Li
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  3. Xiaojing Li
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  4. Xiuying Wang
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  5. Haixia Zhu
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  6. Wei Liang
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  7. Huici Liang
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  8. Wenxiong Chen
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Bingwei Peng, Jialing Li, Xiaojing Li, Xiuying Wang, Haixia Zhu, Wei Liang, Huici Liang and Wenxiong Chen. The first draft of the manuscript was written by Bingwei Peng and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Bingwei Peng.

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Peng, B., Li, J., Li, X. et al. Neuropsychological Deficits in Patients with Electrical Status Epilepticus During Sleep: A Non-invasive Analysis of Neurovascular Coupling. Brain Topogr 33, 375–383 (2020). https://doi.org/10.1007/s10548-020-00759-4

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  • DOI: https://doi.org/10.1007/s10548-020-00759-4

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