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Towards a Universal Taxonomy of Macro-scale Functional Human Brain Networks

Brain Topography volume 32, pages 926–942 (2019)Cite this article

Abstract

The past decade has witnessed a proliferation of studies aimed at characterizing the human connectome. These projects map the brain regions comprising large-scale systems underlying cognition using non-invasive neuroimaging approaches and advanced analytic techniques adopted from network science. While the idea that the human brain is composed of multiple macro-scale functional networks has been gaining traction in cognitive neuroscience, the field has yet to reach consensus on several key issues regarding terminology. What constitutes a functional brain network? Are there “core” functional networks, and if so, what are their spatial topographies? What naming conventions, if universally adopted, will provide the most utility and facilitate communication amongst researchers? Can a taxonomy of functional brain networks be delineated? Here we survey the current landscape to identify six common macro-scale brain network naming schemes and conventions utilized in the literature, highlighting inconsistencies and points of confusion where appropriate. As a minimum recommendation upon which to build, we propose that a scheme incorporating anatomical terminology should provide the foundation for a taxonomy of functional brain networks. A logical starting point in this endeavor might delineate systems that we refer to here as “occipital”, “pericentral”, “dorsal frontoparietal”, “lateral frontoparietal”, “midcingulo-insular”, and “medial frontoparietal” networks. We posit that as the field of network neuroscience matures, it will become increasingly imperative to arrive at a taxonomy such as that proposed here, that can be consistently referenced across research groups.

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Acknowledgements

LQU is supported by the National Institute of Mental Health (R01MH107549), the Canadian Institute for Advanced Research, and a University of Miami Gabelli Senior Scholar Award. RNS is supported by the Natural Sciences and Engineering Research Council of Canada and Canadian Institutes of Health Research, and is a Research Scholar supported by Fonds de recherche du Québec – Santé. BTTY is supported by the Singapore National Research Foundation (NRF) Fellowship (Class of 2017). The authors gratefully acknowledge Roberto Toro and Evan Gordan for assistance with figures.

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Authors and Affiliations

  1. Department of Psychology, University of Miami, P.O. Box 248185-0751, Coral Gables, FL, 33124, USA

    Lucina Q. Uddin

  2. Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL, USA

    Lucina Q. Uddin

  3. Department of Electrical & Computer Engineering, Clinical Imaging Research Centre, Centre for Sleep & Cognition, N.1 Institute for Health & Memory Network Program, National University of Singapore, Singapore, Singapore

    B. T. Thomas Yeo

  4. Laboratory of Brain and Cognition, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montreal, QC, H3A 2B4, Canada

    R. Nathan Spreng

  5. Departments of Psychiatry and Psychology, McGill University, Montreal, QC, Canada

    R. Nathan Spreng

Authors
  1. Lucina Q. Uddin
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  2. B. T. Thomas Yeo
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  3. R. Nathan Spreng
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Corresponding authors

Correspondence to Lucina Q. Uddin or R. Nathan Spreng.

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This is one of several papers published together in Brain Topography on the “Special Issue: Current Opinions in Brain Imaging Methods and Applications”.

Handling Editor: Christoph M. Michel.

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Uddin, L.Q., Yeo, B.T.T. & Spreng, R.N. Towards a Universal Taxonomy of Macro-scale Functional Human Brain Networks. Brain Topogr 32, 926–942 (2019). https://doi.org/10.1007/s10548-019-00744-6

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  • DOI: https://doi.org/10.1007/s10548-019-00744-6

Keywords

  • Coactivation
  • Functional connectivity
  • Human connectome
  • Network neuroscience