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Attenuation and Delay of Remote Potentials Evoked by Direct Electrical Stimulation During Brain Surgery

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Abstract

Direct electrical stimulation (DES) is used to perform functional brain mapping during awake surgery but its electrophysiological effects remain by far unknown. DES may be coupled with the measurement of evoked potentials (EPs) to study the conductive and integrative properties of activated neural ensembles and probe the spatiotemporal dynamics of short- and long-range networks. We recorded ECoG signals on two patients undergoing awake brain surgery and measured EPs on functional sites after cortical stimulations, using combinations of stimulation parameters. EPs were similar in shape but delayed in time and attenuated in amplitude when elicited from a different gyrus or remotely from the recording site. We were able to trigger remote EPs using low stimulation intensities. We propose different activation and electrophysiological propagation mechanisms following DES based on activated neural elements.

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References

  • Adrian E (1936) The spread of activity in the cerebral cortex. J Physiol 88(2):127–161

    Article  CAS  Google Scholar 

  • Boyer A, Duffau H, Vincent M, Ramdani S, Mandonnet E, Guiraud V, Bonnetblanc V (2018) Electrophysiological activity evoked by direct electrical stimulation of the human brain: interest of the P0 component. In: Conference Proceedings: IEEE Engineering in Medicine and Biology Society, pp 2210–2213

  • Duffau H (2015) Stimulation mapping of white matter tracts to study brain functional connectivity. Nat Rev Neurol 11:255–265

    Article  Google Scholar 

  • Goldring S, Jerva MJ, Holmes TG, O’Leary JL, Shields JR (1961) Direct response of human cerebral cortex. Arch Neurol 4:22–30

    Article  Google Scholar 

  • Goldring S, Harding GW, Gregorie EM (1994) Distinctive electrophysiological characteristics of functionally discrete brain areas: a tenable approach to functional localization. J Neurosurg 80:701–709

    Article  CAS  Google Scholar 

  • Kobayashi K, Matsumoto R, Matsuhashi M, Usami K, Shimotake A, Kunieda T, Kikuchi T, Yoshida K, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A (2017) High frequency activity overriding cortico-cortical evoked potentials reflects altered excitability in the human epileptic focus. Clin Neurophysiol 128(9):1673–1681

    Article  Google Scholar 

  • Li CL, Chou SN (1962) Cortcial intracellular synaptic potentials and direct cortical stimulation? J Cell Comp Physiol 60:1–16

    Article  CAS  Google Scholar 

  • Mandonnet E, Winkler PA, Duffau H (2010) Direct electrical stimulation as an input gate into brain functional networks: principles, advantages and limitations. Acta Neurochir (Wien) 152:185–193

    Article  Google Scholar 

  • Matsumoto R, Nair DR, LaPresto E, Najm I, Bingaman W, Shibasaki H, Lüders HO (2004) Functional connectivity in the human language system: a cortico-cortical evoked potential study. Brain 127(10):2316–2330

    Article  Google Scholar 

  • Shimada S, Kunnii N, Kawai K, Matsuo T, Ishishita Y, Ibayashi K, Saito N (2017) Impact of volume-conducted potential in interpretation of cortico-cortical evoked potential: detailed analysis of high-resolution electrocorticography using two mathematical approaches. Clin Neurophysiol 128(4):549–557

    Article  Google Scholar 

  • Vincent M, Rossel O, Hayashibe M, Herbet G, Duffau H, Guiraud D, Bonnetblanc F (2016) The difference between electrical microstimulation and direct electrical stimulation—towards new opportunities for innovative functional brain mapping? Rev Neurosci 27(3):231–258

    PubMed  Google Scholar 

  • Vincent M, Guiraud D, Duffau H, Mandonnet E, Bonnetblanc F (2017) Electrophysiological brain mapping: basics of recording evoked potentials induced by electrical stimulation and its physiological spreading in the human brain. Clin Neurophysiol 128(10):1886–1890

    Article  Google Scholar 

  • Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S (2014) Intraoperative dorsal language network mapping by using single-pulse electrical stimulation. Hum Brain Mapp 35(9):4345–4361

    Article  Google Scholar 

Download references

Funding

Research supported by the LabEx NUMEV project (n° ANR-10-LABX-20) funded by the French government’s “Investissements d’Avenir” program managed by the French National Research Agency (ANR) and complementary grants from the Institut Universitaire de France and INSERM laboratory (U1093).

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Authors and Affiliations

  1. CAMIN, INRIA, LIRMM, Université de Montpellier, 34090, Montpellier, France

    Anthony Boyer, Marion A. Vincent, David Guiraud & Francois Bonnetblanc

  2. Plasticité Cérébrale, Cellules Souches Neurales et Tumeurs Gliales, INSERM U1051, Institut des Neurosciences de Montpellier, 34295, Montpellier, France

    Hugues Duffau

  3. Département de Neurochirurgie, Centre Hospitalier Régional Universitaire de Montpellier Gui de Chauliac, 34295, Montpellier, France

    Hugues Duffau

  4. Département de Neurochirurgie, Hopital Lariboisière, Paris, France

    Emmanuel Mandonnet

  5. SCALab - Sciences Cognitives et Sciences Affectives, CNRS, UMR 9193, Université de Lille, 59000, Lille, France

    Marion A. Vincent

  6. IDH, LIRMM, Université de Montpellier, 34095, Montpellier, France

    Sofiane Ramdani

  7. Institut Universitaire de France, 75231, Paris, France

    Francois Bonnetblanc

  8. Cognition Action et Plasticité Sensorimotrice, INSERM U1093, UFR STAPS, Université Bourgogne Franche-Comté, 21078, Dijon, France

    Francois Bonnetblanc

Authors
  1. Anthony Boyer
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  2. Hugues Duffau
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  3. Emmanuel Mandonnet
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  4. Marion A. Vincent
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  5. Sofiane Ramdani
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  6. David Guiraud
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  7. Francois Bonnetblanc
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Corresponding authors

Correspondence to David Guiraud or Francois Bonnetblanc.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

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Handling Editor: Christian-George Bénar, PhD.

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Boyer, A., Duffau, H., Mandonnet, E. et al. Attenuation and Delay of Remote Potentials Evoked by Direct Electrical Stimulation During Brain Surgery. Brain Topogr 33, 143–148 (2020). https://doi.org/10.1007/s10548-019-00732-w

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  • DOI: https://doi.org/10.1007/s10548-019-00732-w

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