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Comparison of Brain Networks During Interictal Oscillations and Spikes on Magnetoencephalography and Intracerebral EEG

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Abstract

Electromagnetic source localization in electroencephalography (EEG) and magnetoencephalography (MEG) allows finding the generators of transient interictal epileptiform discharges (‘interictal spikes’). In intracerebral EEG (iEEG), oscillatory activity (above 30 Hz) has also been shown to be a marker of neuronal dysfunction. Still, the difference between networks involved in transient and oscillatory activities remains largely unknown. Our goal was thus to extract and compare the networks involved in interictal oscillations and spikes, and to compare the non-invasive results to those obtained directly within the brain. In five patients with both MEG and iEEG recordings, we computed correlation graphs across regions, for (1) interictal spikes and (2) epileptic oscillations around 30 Hz. We show that the corresponding networks can involve a widespread set of regions (average of 10 per patient), with only partial overlap (38 % of the total number of regions in MEG, 50 % in iEEG). The non-invasive results were concordant with intracerebral recordings (79 % for the spikes and 50 % for the oscillations). We compared our interictal results to iEEG ictal data. The regions labeled as seizure onset zone (SOZ) belonged to interictal networks in a large proportion of cases: 75 % (resp. 58 %) for spikes and 58 % (resp. 33 %) for oscillations in iEEG (resp. MEG). A subset of SOZ regions were detected by one type of discharges but not the other (25 % for spikes and 8 % for oscillations). Our study suggests that spike and oscillatory activities involve overlapping but distinct networks, and are complementary for presurgical mapping.

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Acknowledgments

The authors thank Jean Marc Lina, Olivier David, Michael Scherg and Catherine Liegeois-Chauvel for useful discussions. N. Jmail was supported by an Averroes grant from the European Community and a Campus France travelling grant. The authors also wish to thank the anonymous reviewers for their useful comments. Part of this work was funded by a joint Agence Nationale de la Recherche (ANR) and Direction Génerale de l’Offre de Santé (DGOS) under grant ‘VIBRATIONS’ ANR 13 PRTS 0011 01.

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Authors and Affiliations

  1. Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, 13005, Marseille, France

    Nawel Jmail, Martine Gavaret, F. Bartolomei, P. Chauvel, Jean-Michel Badier & Christian-G. Bénar

  2. APHM, Hôpital de la Timone, Neurophysiologie clinique, 13005, Marseille, France

    Martine Gavaret, F. Bartolomei & P. Chauvel

  3. ENIS, MIRACL Laboratory, Sfax University, Sfax, Tunisia

    Nawel Jmail

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  1. Nawel Jmail
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  2. Martine Gavaret
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  3. F. Bartolomei
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  4. P. Chauvel
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  5. Jean-Michel Badier
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  6. Christian-G. Bénar
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Correspondence to Christian-G. Bénar.

Electronic supplementary material

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10548_2016_501_MOESM1_ESM.docx

Supplementary Table 1 Regions involved in spikes and oscillations in MEG and iEEG and concordance between regions presenting network nodes

10548_2016_501_MOESM2_ESM.docx

Supplementary Table 2 List of sensor coordinates that are concordant between MEG and iEEG for spikes and oscillations in the 5 patients (when several IEEG contacts were present, only closest matches are shown).

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Jmail, N., Gavaret, M., Bartolomei, F. et al. Comparison of Brain Networks During Interictal Oscillations and Spikes on Magnetoencephalography and Intracerebral EEG. Brain Topogr 29, 752–765 (2016). https://doi.org/10.1007/s10548-016-0501-7

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  • DOI: https://doi.org/10.1007/s10548-016-0501-7

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