Skip to main content
Log in

Two Intrinsic Coupling Types for Resting-State Integration in the Human Brain

  • Original Paper
  • Published:
Brain Topography Aims and scope Submit manuscript

Abstract

Recent findings indicate that synchronous neural activity at rest influences human performance in subsequent tasks. Synchronization can occur in form of phase coupling or amplitude correlation. It is unknown whether these coupling types have differing behavioral significance at rest. To address this, we performed resting-state electroencephalography (EEG) and source connectivity analysis in several populations of healthy subjects and patients with brain lesions. We systematically compared different types and frequencies of neural synchronization and investigated their association with behavioral performance in verbal and spatial attention tasks. Behavioral performance could be consistently predicted by two distinct resting-state coupling patterns: (1) amplitude envelope correlation of beta activity between homologous areas of both hemispheres, (2) lagged phase synchronization in EEG alpha activity between a brain area and the entire cortex. A disruption of these coupling patterns was also associated with neurological deficits in patients with stroke lesions. This suggests the existence of two distinct network systems responsible for resting-state integration. Lagged phase synchronization in the alpha band is associated with global interaction across networks while amplitude envelope correlation seems to be behaviorally relevant for interactions within networks and between hemispheres. These two coupling types may therefore provide complementary insights on brain physiology and pathology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

Download references

Acknowledgments

Research was supported by the Swiss National Science Foundation (Grants 320030_129679 and 320030_146639). We would like to thank Prof. Andreas Kleinschmidt, University of Geneva, Drs. Johanna Zumer and Jan-Mathijs Schoffelen, Radboud Universiteit Nijmegen, and Dr. Sarang Dalal, University of Konstanz, for helpful comments.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Adrian G. Guggisberg.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 52 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Guggisberg, A.G., Rizk, S., Ptak, R. et al. Two Intrinsic Coupling Types for Resting-State Integration in the Human Brain. Brain Topogr 28, 318–329 (2015). https://doi.org/10.1007/s10548-014-0394-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10548-014-0394-2

Keywords

Navigation