Brain Topography

, Volume 26, Issue 1, pp 171–176 | Cite as

Anatomical and Electrophysiological Manifestations in a Patient with Congenital Corpus Callosum Agenesis

Brief Communication

Abstract

The corpus callosum is the major brain structure responsible for the transferring of information between the two hemispheres. In congenital agenesis of the corpus callosum (ACC), an alternative functional connection might exist between the hemispheres; however, this has yet to be demonstrated. The present study evaluated a 27-year-old man with ACC but no detectable motor function deficits using diffusion tensor imaging (DTI), movement-related cortical potential (MRCP), and interhemispheric inhibition (IHI). The MRCP was analyzed at the electrodes of C3, FCZ, and C4. IHI was measured using paired transcranial magnetic stimulation over the hand area of the primary motor cortex at both hemispheres. Data of the patient were compared with those of an age-matched healthy control group (n = 8, mean age: 27.6 ± 2.5 years). DTI showed absence of the callosal fibers and the presence of enhanced transcommissural fibers in the ACC patient. The mean fractional anisotropy of the transcommissural fibers revealed a significant difference between the patient and the control group (0.62 vs. 0.43, p < 0.01). The MRCP and IHI, supposed to be highly relevant to the transcallosal pathway, were present in the patient though they occurred to a relatively low degree compared to the control group. Findings suggest that in the ACC patient, the abnormal transcommissural fibers might be functional and serve as an alternative pathway connecting the bilateral hemispheres.

Keywords

Agenesis of corpus callosum Anterior commissure Diffusion tensor imaging (DTI) Interhemispheric inhibition (IHI) Movement-related cortical potential (MRCP) 

Notes

Acknowledgments

This work has been supported by the grants from the National Science Council (99-2314-B-039-017-MY2; NSC 101-2314-B-039-026), Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH101-TD-B-111-004) and “Aim for the Top University Plan” of the National Chiao Tung University and Ministry of Education, Taiwan.

References

  1. Allison JD, Meador KJ, Loring DW, Figueroa RE, Wright JC (2000) Functional MRI cerebral activation and deactivation during finger movement. Neurology 54:135–142PubMedCrossRefGoogle Scholar
  2. Chen R, Yung D, Li JY (2003) Organization of ipsilateral excitatory and inhibitory pathways in the human motor cortex. J Neurophysiol 89:1256–1264PubMedCrossRefGoogle Scholar
  3. Ferbert A, Priori A, Rothwell JC, Day BL, Colebatch JG, Marsden CD (1992) Interhemispheric inhibition of the human motor cortex. J Physiol 453:525–546PubMedGoogle Scholar
  4. Gerloff C, Richard J, Hadley J, Schulman AE, Honda M, Hallett M (1998) Functional coupling and regional activation of human cortical motor areas during simple, internally paced and externally paced finger movements. Brain 121(Pt 8):1513–1531PubMedCrossRefGoogle Scholar
  5. Giovannelli F, Borgheresi A, Balestrieri F, Zaccara G, Viggiano MP, Cincotta M, Ziemann U (2009) Modulation of interhemispheric inhibition by volitional motor activity: an ipsilateral silent period study. J Physiol 587:5393–5410PubMedCrossRefGoogle Scholar
  6. Lee SK, Mori S, Kim DJ, Kim SY, Kim SY, Kim DI (2004) Diffusion tensor MR imaging visualizes the altered hemispheric fiber connection in callosal dysgenesis. AJNR Am J Neuroradiol 25:25–28PubMedGoogle Scholar
  7. Lu MK, Shih HT, Huang KJ, Ziemann U, Tsai CH, Chang FC, Chen YC, Lin YT, Huang WS, Lee CC, Liu CS (2008) Movement-related cortical potentials in patients with Machado–Joseph disease. Clin Neurophysiol 119:1010–1019PubMedCrossRefGoogle Scholar
  8. Meyer BU, Roricht S, von Grafin EH, Kruggel F, Weindl A (1995) Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum. Brain 118(Pt 2):429–440PubMedCrossRefGoogle Scholar
  9. Meyer BU, Roricht S, Niehaus L (1998a) Morphology of acallosal brains as assessed by MRI in six patients leading a normal daily life. J Neurol 245:106–110PubMedCrossRefGoogle Scholar
  10. Meyer BU, Roricht S, Woiciechowsky C (1998b) Topography of fibers in the human corpus callosum mediating interhemispheric inhibition between the motor cortices. Ann Neurol 43:360–369PubMedCrossRefGoogle Scholar
  11. Oldfield R (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97–113PubMedCrossRefGoogle Scholar
  12. Paul LK, Brown WS, Adolphs R, Tyszka JM, Richards LJ, Mukherjee P, Sherr EH (2007) Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity. Nat Rev Neurosci 8:287–299PubMedCrossRefGoogle Scholar
  13. Rektor I, Bares M, Kubova D (2001) Movement-related potentials in the basal ganglia: a SEEG readiness potential study. Clin Neurophysiol 112:2146–2153PubMedCrossRefGoogle Scholar
  14. Rossi S, Hallett M, Rossini P, Pascual-Leone A (2009) Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol 120:2008–2039PubMedCrossRefGoogle Scholar
  15. Shibasaki H, Hallett M (2006) What is the Bereitschaftspotential? Clin Neurophysiol 117:2341–2356PubMedCrossRefGoogle Scholar
  16. Stancák A Jr, Lücking CH, Kristeva-Feige R (2000) Lateralization of movement-related potentials and the size of corpus callosum. NeuroReport 11:329–332PubMedCrossRefGoogle Scholar
  17. Stancák A, Cohen ER, Seidler RD, Duong TQ, Kim SG (2003) The size of corpus callosum correlates with functional activation of medial motor cortical areas in bimanual and unimanual movements. Cereb Cortex 13:475–485PubMedCrossRefGoogle Scholar
  18. Taylor M, David AS (1998) Agenesis of the corpus callosum: a United Kingdom series of 56 cases. J Neurol Neurosurg Psychiatry 64:131–134PubMedCrossRefGoogle Scholar
  19. Tovar-Moll F, Moll J, de Oliveira-Souza R, Bramati I, Andreiuolo PA, Lent R (2007) Neuroplasticity in human callosal dysgenesis: a diffusion tensor imaging study. Cereb Cortex 17:531–541PubMedCrossRefGoogle Scholar
  20. Utsunomiya H, Yamashita S, Takano K, Okazaki M (2006) Arrangement of fiber tracts forming Probst bundle in complete callosal agenesis: report of two cases with an evaluation by diffusion tensor tractography. Acta Radiol 47:1063–1066PubMedCrossRefGoogle Scholar
  21. Wahl M, Lauterbach-Soon B, Hattingen E, Jung P, Singer O, Volz S, Klein JC, Steinmetz H, Ziemann U (2007) Human motor corpus callosum: topography, somatotopy, and link between microstructure and function. J Neurosci 27:12132–12138PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Neuroscience Laboratory, Department of NeurologyChina Medical University HospitalTaichungTaiwan
  2. 2.Biomedical Engineering Research Center and Graduate Institute of Clinical and Medical Science, China Medical University HospitalTaichungTaiwan
  3. 3.Department of RadiologyChina Medical University HospitalTaichungTaiwan
  4. 4.School of MedicineMedical College, China Medical UniversityTaichungTaiwan
  5. 5.Graduate Institute of Neural and Cognitive SciencesChina Medical UniversityTaichungTaiwan
  6. 6.Institute of Neural ComputationUniversity of CaliforniaSan DiegoUSA

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